ID   CRBLH_VESMG             Reviewed;          65 AA.
AC   A0SPI1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Vespid chemotactic peptide 5h;
DE            Short=VCP 5h;
DE   Flags: Precursor;
OS   Vespa magnifica (Hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=202807;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 50-62, AND AMIDATION AT
RP   LEU-62.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=17573088; DOI=10.1016/j.toxicon.2007.04.023;
RA   Yu H., Yang H., Ma D., Lv Y., Liu T., Zhang K., Lai R., Liu J.;
RT   "Vespid chemotactic peptide precursor from the wasp, Vespa magnifica
RT   (Smith).";
RL   Toxicon 50:377-382(2007).
CC   -!- FUNCTION: Induces chemotaxis. Shows antimicrobial activity against the
CC       Gram-negative bacteria E.coli ATCC 25922 (MIC=30 ug/ml), the Gram-
CC       positive bacteria S.aureus ATCC 2592 (MIC=5 ug/ml) and the fungus
CC       C.albicans ATCC 2002 (MIC=25 ug/ml).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the MCD family. Crabrolin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ865261; ABI94580.1; -; mRNA.
DR   AlphaFoldDB; A0SPI1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Chemotaxis;
KW   Direct protein sequencing; Fungicide; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..49
FT                   /evidence="ECO:0000269|PubMed:17573088"
FT                   /id="PRO_0000305122"
FT   PEPTIDE         50..62
FT                   /note="Vespid chemotactic peptide 5h"
FT                   /id="PRO_0000305123"
FT   REPEAT          23..26
FT                   /note="AXPX 1"
FT   REPEAT          27..30
FT                   /note="AXPX 2"
FT   REPEAT          31..34
FT                   /note="AXPX 3"
FT   REPEAT          35..38
FT                   /note="AXPX 4"
FT   REPEAT          39..42
FT                   /note="AXPX 5"
FT   REPEAT          43..46
FT                   /note="AXPX 6"
FT   REPEAT          47..50
FT                   /note="AXPX 7"
FT   MOD_RES         62
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:17573088"
SQ   SEQUENCE   65 AA;  6621 MW;  EC1EF90CAC739B4E CRC64;
     MKYNIVFLFA IIASLACLQL TFAAPAASPL ANPGASPDAA PNADPLADPF LPIIGKLLSG
     LLGKK