ID   CRCB1_BIFLO             Reviewed;         131 AA.
AC   Q8G6U1;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=BL0547;
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AE014295; AAN24371.1; -; Genomic_DNA.
DR   RefSeq; NP_695735.1; NC_004307.2.
DR   RefSeq; WP_007051665.1; NC_004307.2.
DR   AlphaFoldDB; Q8G6U1; -.
DR   SMR; Q8G6U1; -.
DR   STRING; 206672.BL0547; -.
DR   EnsemblBacteria; AAN24371; AAN24371; BL0547.
DR   KEGG; blo:BL0547; -.
DR   PATRIC; fig|206672.9.peg.1290; -.
DR   HOGENOM; CLU_745282_0_0_11; -.
DR   OMA; FALICMC; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..131
FT                   /note="Putative fluoride ion transporter CrcB 1"
FT                   /id="PRO_0000110059"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   131 AA;  14201 MW;  6A7F4BD445ABFA1F CRC64;
     MMWMICLFGG LGAMARYVLD VSIQRGWNRE NRRTNRNFPL STLVINGVAS LCAGIAMMSY
     YSQSVDMDTV MMFVVGFLGG FSTFSTALNE VVSLIRQRRF TLALGYGIAT VAVPLICVAA
     GFGIALLANP A