CRCB1_BRUAB
ID CRCB1_BRUAB Reviewed; 270 AA.
AC Q57CD7;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN OrderedLocusNames=BruAb1_1366;
OS Brucella abortus biovar 1 (strain 9-941).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=262698;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9-941;
RX PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT "Completion of the genome sequence of Brucella abortus and comparison to
RT the highly similar genomes of Brucella melitensis and Brucella suis.";
RL J. Bacteriol. 187:2715-2726(2005).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; AE017223; AAX74697.1; -; Genomic_DNA.
DR RefSeq; WP_002964481.1; NC_006932.1.
DR AlphaFoldDB; Q57CD7; -.
DR SMR; Q57CD7; -.
DR EnsemblBacteria; AAX74697; AAX74697; BruAb1_1366.
DR GeneID; 45124720; -.
DR KEGG; bmb:BruAb1_1366; -.
DR HOGENOM; CLU_1029234_0_0_5; -.
DR OMA; EFIMLMM; -.
DR Proteomes; UP000000540; Chromosome I.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 3.30.310.70; -; 1.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR InterPro; IPR005180; DUF302.
DR InterPro; IPR035923; TT1751-like_sf.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
DR Pfam; PF03625; DUF302; 1.
DR SUPFAM; SSF103247; SSF103247; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..270
FT /note="Putative fluoride ion transporter CrcB 1"
FT /id="PRO_0000110067"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 270 AA; 28330 MW; AEF8788029A5E1A8 CRC64;
MLDIIILVVI GGAFGAMTRE FIMLMVPPLT DGFPLDILVA NVVACFLLGT VTALYARKIH
SRDVHTIIGT GMMGGVSTFS SFAYGSVVLA SASMSAFLIA AAYVTVSVVA GYVAVLAGMK
FGEKSADILH RYPPMASIID SGLVTVESRH SVAETIERVA AKAKSMGMNV FTRVDHGAGA
KEAGLGLPPT ELIIFGNPQN GTVLMQDKRT IGLDLPIRAL AWEDGSGKVW LTVNDPAWLA
QRHSLGLSSD VAIKAMVTGT GTVTKYAAGD