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CRCB1_BRUSU
ID   CRCB1_BRUSU             Reviewed;         254 AA.
AC   Q8FZV1; G0KB54;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   OrderedLocusNames=BR1369, BS1330_I1364;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AE014291; AAN30283.1; -; Genomic_DNA.
DR   EMBL; CP002997; AEM18700.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8FZV1; -.
DR   SMR; Q8FZV1; -.
DR   EnsemblBacteria; AEM18700; AEM18700; BS1330_I1364.
DR   KEGG; bms:BR1369; -.
DR   KEGG; bsi:BS1330_I1364; -.
DR   HOGENOM; CLU_1029234_0_0_5; -.
DR   OMA; EFIMLMM; -.
DR   Proteomes; UP000007104; Chromosome I.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   Gene3D; 3.30.310.70; -; 1.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   InterPro; IPR005180; DUF302.
DR   InterPro; IPR035923; TT1751-like_sf.
DR   Pfam; PF02537; CRCB; 1.
DR   Pfam; PF03625; DUF302; 1.
DR   SUPFAM; SSF103247; SSF103247; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..254
FT                   /note="Putative fluoride ion transporter CrcB 1"
FT                   /id="PRO_0000110075"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   254 AA;  26808 MW;  9AD334D39C4A0987 CRC64;
     MTREFIMLMM PPLTDGFPLD ILVANVVACF LLGTVTALYA RKIHSRDVHT IIGMGMMGGV
     STFSSFAYGS VVLASASMSA FLIAAAYVTV SVVAGYVAVL AGMKFGEKSA DILHRYPPMA
     SIIDSGLVTV ESRHSVAETI ERVAAKAKSM GMNVFTRVDH GAGAKEAGLG LPPTELIIFG
     NPQNGTVLMQ DKRTIGLDLP IRALAWEDGS GKVWLTVNDP AWLAQRHSLG LSSDVAIKAM
     VTGTGTVTKY AAGD
 
 
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