ID   CRCB1_CUTAK             Reviewed;         143 AA.
AC   Q6A9P0;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=PPA0770;
OS   Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium
OS   acnes).
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=267747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16379 / KPA171202;
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal of
RT   human skin.";
RL   Science 305:671-673(2004).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AE017283; AAT82526.1; -; Genomic_DNA.
DR   RefSeq; WP_002523752.1; NC_006085.1.
DR   AlphaFoldDB; Q6A9P0; -.
DR   SMR; Q6A9P0; -.
DR   STRING; 267747.PPA0770; -.
DR   EnsemblBacteria; AAT82526; AAT82526; PPA0770.
DR   KEGG; pac:PPA0770; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_1_1_11; -.
DR   OMA; EWRLFLI; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..143
FT                   /note="Putative fluoride ion transporter CrcB 1"
FT                   /id="PRO_0000110149"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   143 AA;  15060 MW;  8E682FA74A94C848 CRC64;
     MAMRSGFLDR RPVLVGLVFL GGCLGTLIRS VIAHAWPSRA DGVPWGTLAI NLVGAFVLAT
     LLELLVHAGP DRGVRRAVRL CIGTGLLGGF TTYSALTVEA GQRVMSGQWL WGIAYLLTSV
     AAGALLAWVV IAAVRCVMGK RSS