CRCB1_FRACC
ID CRCB1_FRACC Reviewed; 129 AA.
AC Q2JAK2;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN OrderedLocusNames=Francci3_2322;
OS Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3).
OC Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=106370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45818 / CECT 9043 / CcI3;
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; CP000249; ABD11690.1; -; Genomic_DNA.
DR RefSeq; WP_011436736.1; NZ_LRTJ01000027.1.
DR AlphaFoldDB; Q2JAK2; -.
DR SMR; Q2JAK2; -.
DR STRING; 106370.Francci3_2322; -.
DR EnsemblBacteria; ABD11690; ABD11690; Francci3_2322.
DR KEGG; fra:Francci3_2322; -.
DR eggNOG; COG0239; Bacteria.
DR HOGENOM; CLU_114342_2_1_11; -.
DR OMA; FLMFESF; -.
DR OrthoDB; 1942863at2; -.
DR PhylomeDB; Q2JAK2; -.
DR Proteomes; UP000001937; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..129
FT /note="Putative fluoride ion transporter CrcB 1"
FT /id="PRO_0000252883"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 129 AA; 12917 MW; 549B495D6C0D7D1A CRC64;
MNWLLVIAGA AAGAPLRYLT DRAVQTRHDT VFPWGTFTVN VTASLLLGLV AGAAGAGAPP
AWVASEQVVS LVGTGLCGAL STYSTFSYET LRLAEDGARL LAAANVAGSV LAAFGAAALG
AALARAVWG