CRCB1_METBF
ID CRCB1_METBF Reviewed; 116 AA.
AC Q46F67;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=Mbar_A0493;
OS Methanosarcina barkeri (strain Fusaro / DSM 804).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=269797;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fusaro / DSM 804;
RX PubMed=16980466; DOI=10.1128/jb.00810-06;
RA Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT "The Methanosarcina barkeri genome: comparative analysis with
RT Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT rearrangement within methanosarcinal genomes.";
RL J. Bacteriol. 188:7922-7931(2006).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAZ69475.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000099; AAZ69475.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q46F67; -.
DR SMR; Q46F67; -.
DR STRING; 269797.Mbar_A0493; -.
DR EnsemblBacteria; AAZ69475; AAZ69475; Mbar_A0493.
DR KEGG; mba:Mbar_A0493; -.
DR eggNOG; arCOG04701; Archaea.
DR HOGENOM; CLU_114342_3_2_2; -.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
DR TIGRFAMs; TIGR00494; crcB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..116
FT /note="Putative fluoride ion transporter CrcB 1"
FT /id="PRO_0000252962"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 116 AA; 12517 MW; A28479FFE31CF71C CRC64;
MGKLFLIGAG GFIGACLRYT VSSQVPRIKN IPAGTLTVNL LGTIVLAFLT FSSEPQSMVY
LVNIGILGSF TTFSTFAYET FKLLEEGQNF SFFLNIFLNV ALCLVGVSIA YLALSL