CRCB1_MYCBO
ID CRCB1_MYCBO Reviewed; 132 AA.
AC P63863; A0A1R3Y313; P95089; X2BMZ5;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN OrderedLocusNames=BQ2027_MB3096;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; LT708304; SIU01721.1; -; Genomic_DNA.
DR RefSeq; NP_856741.1; NC_002945.3.
DR RefSeq; WP_003416045.1; NC_002945.4.
DR AlphaFoldDB; P63863; -.
DR SMR; P63863; -.
DR EnsemblBacteria; SIU01721; SIU01721; BQ2027_MB3096.
DR GeneID; 45427063; -.
DR PATRIC; fig|233413.5.peg.3401; -.
DR OMA; EWRLFLI; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..132
FT /note="Putative fluoride ion transporter CrcB 1"
FT /id="PRO_0000110133"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 132 AA; 14301 MW; CA9B283379B0174E CRC64;
MPNHDYRELA AVFAGGALGA LARAALSALA IPDPARWPWP TFTVNVVGAF LVGYFTTRLL
ERLPLSSYRR PLLGTGLCGG LTTFSTMQVE TISMIEHGHW GLAAAYSVVS ITLGLLAVHL
ATVLVRRVRI RR