ID   CRCB1_PROMT             Reviewed;         114 AA.
AC   Q46IH8;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=PMN2A_1210;
OS   Prochlorococcus marinus (strain NATL2A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL2A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; CP000095; AAZ58700.1; -; Genomic_DNA.
DR   RefSeq; WP_011295554.1; NC_007335.2.
DR   AlphaFoldDB; Q46IH8; -.
DR   SMR; Q46IH8; -.
DR   STRING; 59920.PMN2A_1210; -.
DR   EnsemblBacteria; AAZ58700; AAZ58700; PMN2A_1210.
DR   KEGG; pmn:PMN2A_1210; -.
DR   HOGENOM; CLU_114342_2_1_3; -.
DR   OMA; WISRKIT; -.
DR   OrthoDB; 1942863at2; -.
DR   PhylomeDB; Q46IH8; -.
DR   Proteomes; UP000002535; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..114
FT                   /note="Putative fluoride ion transporter CrcB 1"
FT                   /id="PRO_0000252911"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   114 AA;  12845 MW;  52942CB0D038FC37 CRC64;
     MGIDIKNNTF FLISLGAFLG ALFRWQIDEI FIVNLIGCFL LGFFNSLNIL KRYKLTLCVG
     LCGSMTTFSS WMSHLYKLLN QGLYKLFLLN SLSIVLMGVL SIALGHIFAK RLNA