CRCB1_STAAN
ID CRCB1_STAAN Reviewed; 147 AA.
AC P61384; Q99T86;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=SA1601;
OS Staphylococcus aureus (strain N315).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N315;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; BA000018; BAB42869.1; -; Genomic_DNA.
DR PIR; H89963; H89963.
DR AlphaFoldDB; P61384; -.
DR SMR; P61384; -.
DR EnsemblBacteria; BAB42869; BAB42869; BAB42869.
DR KEGG; sau:SA1601; -.
DR HOGENOM; CLU_114342_3_2_9; -.
DR OMA; FLMFESF; -.
DR Proteomes; UP000000751; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
DR TIGRFAMs; TIGR00494; crcB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..147
FT /note="Putative fluoride ion transporter CrcB 1"
FT /id="PRO_0000110177"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 147 AA; 16299 MW; 983D9F95BA020629 CRC64;
MHRQFLSSCC QNLFFKFKLL LFEVNQMQYV YIFIGGALGA LLRYLISFLN TDGGFPIGTL
IANLTGAFVM GLLTALTIAF FSNHPTLKKA ITTGFLGALT TFSTFQLELI HMFDHQQFIT
LLLYAVTSYV FGILLCYVGI KLGGGLS