ID   CRCB1_STRCO             Reviewed;         154 AA.
AC   Q9FC39;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Putative fluoride ion transporter CrcB 1 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB1 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=SCO7044;
GN   ORFNames=SC4G1.10;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AL939130; CAC01542.1; -; Genomic_DNA.
DR   RefSeq; NP_631106.1; NC_003888.3.
DR   RefSeq; WP_011031398.1; NZ_VNID01000012.1.
DR   AlphaFoldDB; Q9FC39; -.
DR   SMR; Q9FC39; -.
DR   STRING; 100226.SCO7044; -.
DR   GeneID; 1102482; -.
DR   KEGG; sco:SCO7044; -.
DR   PATRIC; fig|100226.15.peg.7148; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_1_0_11; -.
DR   InParanoid; Q9FC39; -.
DR   OMA; FPWATFW; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
DR   TIGRFAMs; TIGR00494; crcB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..154
FT                   /note="Putative fluoride ion transporter CrcB 1"
FT                   /id="PRO_0000110192"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   154 AA;  16116 MW;  A1A5C79182DDB1EF CRC64;
     MTVPRTGRPG GIRAAAPSRS GWRTQAPVVA VVALGGGTGA AARYAASLWW PTPAGGFPWT
     TFGVNAVGCA VIGVFMVVIT EVRPAHRLVR PFFGTGVLGG FTTFSTYAVD SRSLFADGRL
     PTGLAYLAAT PLAALTAVWL AAWAARRVLK WRQS