ID   CRCB2_BIFLO             Reviewed;         178 AA.
AC   Q8G5C3;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=BL1091;
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AE014295; AAN24899.1; -; Genomic_DNA.
DR   RefSeq; NP_696263.1; NC_004307.2.
DR   RefSeq; WP_007051196.1; NC_004307.2.
DR   AlphaFoldDB; Q8G5C3; -.
DR   SMR; Q8G5C3; -.
DR   STRING; 206672.BL1091; -.
DR   EnsemblBacteria; AAN24899; AAN24899; BL1091.
DR   GeneID; 66504772; -.
DR   KEGG; blo:BL1091; -.
DR   PATRIC; fig|206672.9.peg.798; -.
DR   HOGENOM; CLU_114342_4_0_11; -.
DR   OMA; ERRYMAR; -.
DR   PhylomeDB; Q8G5C3; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..178
FT                   /note="Putative fluoride ion transporter CrcB 2"
FT                   /id="PRO_0000110060"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   178 AA;  17790 MW;  D9F0AC7E0A5948B1 CRC64;
     MDSQSPSAGA RPITHTTTPP ARKLPDIHLD IVLVVFCGGA IGTAIRYAFA QIPAAGSFHT
     GTFVANMLAC FCYAGLTAYL AGASRFGARS KELASRGLGM GVCGGLSTMS TLALEGFTAI
     RDGQVAAGIA YLLVTFALGL VCASAGVWAG THLAGSSNVS AEASADTNAA TTSKGGKA