CRCB2_BRUME
ID CRCB2_BRUME Reviewed; 270 AA.
AC Q8YI11;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=BMEI0634;
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; AE008917; AAL51815.1; -; Genomic_DNA.
DR PIR; AD3331; AD3331.
DR RefSeq; WP_004683989.1; NZ_GG703780.1.
DR AlphaFoldDB; Q8YI11; -.
DR SMR; Q8YI11; -.
DR STRING; 224914.BMEI0634; -.
DR EnsemblBacteria; AAL51815; AAL51815; BMEI0634.
DR GeneID; 29593419; -.
DR KEGG; bme:BMEI0634; -.
DR PATRIC; fig|224914.52.peg.829; -.
DR eggNOG; COG0239; Bacteria.
DR eggNOG; COG3439; Bacteria.
DR OMA; EFIMLMM; -.
DR PhylomeDB; Q8YI11; -.
DR Proteomes; UP000000419; Chromosome I.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 3.30.310.70; -; 1.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR InterPro; IPR005180; DUF302.
DR InterPro; IPR035923; TT1751-like_sf.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
DR Pfam; PF03625; DUF302; 1.
DR SUPFAM; SSF103247; SSF103247; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..270
FT /note="Putative fluoride ion transporter CrcB 2"
FT /id="PRO_0000110072"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 270 AA; 28298 MW; A5E8739B22B5E1B8 CRC64;
MLDIIILVVI GGAFGAMTRE FIMLMVPPLT DGFPLDILVA NVVACFLLGT VTALYARKIH
SRDVHTIIGT GMMGGVSTFS SFAYGSVVLA SASVSAFLIA AAYVTVSVVA GYVAVLAGMK
FGEKSADILH RYPPMASIID SGLVTVESRH SVAETIERVA AKAKSMGMNV FTRVDHGAGA
KEAGLGLPPT ELIIFGNPQN GTVLMQDKRT IGLDLPIRAL AWEDGSGKVW LTVNDPAWLA
QRHSLGLSSD VAIKAMVTGT GTVTKYAAGD
