CRCB2_CORGL
ID CRCB2_CORGL Reviewed; 108 AA.
AC Q8NMM8;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN OrderedLocusNames=Cgl2543, cg2802;
OS Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS JCM 1318 / LMG 3730 / NCIMB 10025).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=196627;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA Ikeda M., Nakagawa S.;
RT "The Corynebacterium glutamicum genome: features and impacts on
RT biotechnological processes.";
RL Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT impact on the production of L-aspartate-derived amino acids and vitamins.";
RL J. Biotechnol. 104:5-25(2003).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; BA000036; BAB99936.1; -; Genomic_DNA.
DR EMBL; BX927155; CAF21205.1; -; Genomic_DNA.
DR RefSeq; NP_601743.1; NC_003450.3.
DR RefSeq; WP_003860253.1; NC_006958.1.
DR AlphaFoldDB; Q8NMM8; -.
DR SMR; Q8NMM8; -.
DR STRING; 196627.cg2802; -.
DR KEGG; cgb:cg2802; -.
DR KEGG; cgl:Cgl2543; -.
DR PATRIC; fig|196627.13.peg.2476; -.
DR eggNOG; COG0239; Bacteria.
DR HOGENOM; CLU_114342_2_2_11; -.
DR OMA; LARYLFW; -.
DR Proteomes; UP000000582; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..108
FT /note="Putative fluoride ion transporter CrcB 2"
FT /id="PRO_0000110093"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 29..45
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 108 AA; 11819 MW; D562F802EACC52DC CRC64;
MIFLYAALGG FFGGFLRWSL AQLFPGKRAT LAANTLACLA GGFFVSLDLP HLYTVLLIAG
FCGALSTWST LAKELGQLLN EKKWWPMLGY LSLTFTLGYS AVFLGMRL
