ID   CRCB2_LACAC             Reviewed;         124 AA.
AC   Q5FKD1;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=LBA0993;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000033; AAV42843.1; -; Genomic_DNA.
DR   RefSeq; WP_003547161.1; NC_006814.3.
DR   RefSeq; YP_193874.1; NC_006814.3.
DR   AlphaFoldDB; Q5FKD1; -.
DR   SMR; Q5FKD1; -.
DR   STRING; 272621.LBA0993; -.
DR   PRIDE; Q5FKD1; -.
DR   EnsemblBacteria; AAV42843; AAV42843; LBA0993.
DR   GeneID; 56942610; -.
DR   KEGG; lac:LBA0993; -.
DR   PATRIC; fig|272621.13.peg.943; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_2_3_9; -.
DR   OMA; EVMDKDH; -.
DR   BioCyc; LACI272621:G1G49-993-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..124
FT                   /note="Putative fluoride ion transporter CrcB 2"
FT                   /id="PRO_0000110113"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   124 AA;  13786 MW;  3C9E06415ED028B5 CRC64;
     MNFLLAGIGA SIGAMLRYAI TNYGKKHWEW IGNKFSNLPT PTLFINLTGA FILGFIFGIK
     TNVFIYAIVG TGVLGGYTTF STMNTELVEL YKSKNYRGFI FYALSSYLGG LILVFVGYYL
     AILF