ID   CRCB2_NOCFA             Reviewed;         140 AA.
AC   Q5YR85;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=NFA_44550;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AP006618; BAD59306.1; -; Genomic_DNA.
DR   RefSeq; WP_011210990.1; NC_006361.1.
DR   AlphaFoldDB; Q5YR85; -.
DR   SMR; Q5YR85; -.
DR   STRING; 247156.NFA_44550; -.
DR   EnsemblBacteria; BAD59306; BAD59306; NFA_44550.
DR   GeneID; 61135064; -.
DR   KEGG; nfa:NFA_44550; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_1_0_11; -.
DR   OMA; FPWATFW; -.
DR   BioCyc; NFAR247156:NFA_RS22090-MON; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
DR   TIGRFAMs; TIGR00494; crcB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..140
FT                   /note="Putative fluoride ion transporter CrcB 2"
FT                   /id="PRO_0000110144"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   140 AA;  14495 MW;  4485609754377976 CRC64;
     MSAPARVPPL DPAILLAISL GGGLGALLRY LISTWWPTPP GHVPWATFVV NVTGCFAIGV
     LMVLVTEAWV THRLLRPFAG VGLLGGFTTF STYGLEIRTL LESGAVLEAL GYLAGTVLAA
     LAGVVLGTGA ARWATGAARR