CRCB2_STAA8
ID CRCB2_STAA8 Reviewed; 117 AA.
AC Q2FXE5;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN OrderedLocusNames=SAOUHSC_01904;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; CP000253; ABD30967.1; -; Genomic_DNA.
DR RefSeq; WP_000623471.1; NZ_LS483365.1.
DR RefSeq; YP_500405.1; NC_007795.1.
DR AlphaFoldDB; Q2FXE5; -.
DR SMR; Q2FXE5; -.
DR STRING; 1280.SAXN108_1814; -.
DR EnsemblBacteria; ABD30967; ABD30967; SAOUHSC_01904.
DR GeneID; 3920851; -.
DR KEGG; sao:SAOUHSC_01904; -.
DR PATRIC; fig|93061.5.peg.1733; -.
DR eggNOG; COG0239; Bacteria.
DR HOGENOM; CLU_114342_2_3_9; -.
DR OMA; EVMDKDH; -.
DR PRO; PR:Q2FXE5; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..117
FT /note="Putative fluoride ion transporter CrcB 2"
FT /id="PRO_0000252944"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 33..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 117 AA; 12796 MW; 4FF2B1F4124A6732 CRC64;
MISIILVMIG GGFGAIARSA ITDYFNHKFT SKLPIATLIV NLVGSFLIGL TIGLSISISW
FPAFFVTGFL GGLTTFSTLA KELTLMMTPK FNINLFLNYS LLQFIIGFIA CYIGYHI