ID   CRCB2_STAA8             Reviewed;         117 AA.
AC   Q2FXE5;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   OrderedLocusNames=SAOUHSC_01904;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; CP000253; ABD30967.1; -; Genomic_DNA.
DR   RefSeq; WP_000623471.1; NZ_LS483365.1.
DR   RefSeq; YP_500405.1; NC_007795.1.
DR   AlphaFoldDB; Q2FXE5; -.
DR   SMR; Q2FXE5; -.
DR   STRING; 1280.SAXN108_1814; -.
DR   EnsemblBacteria; ABD30967; ABD30967; SAOUHSC_01904.
DR   GeneID; 3920851; -.
DR   KEGG; sao:SAOUHSC_01904; -.
DR   PATRIC; fig|93061.5.peg.1733; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_2_3_9; -.
DR   OMA; EVMDKDH; -.
DR   PRO; PR:Q2FXE5; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..117
FT                   /note="Putative fluoride ion transporter CrcB 2"
FT                   /id="PRO_0000252944"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        33..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        58..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   117 AA;  12796 MW;  4FF2B1F4124A6732 CRC64;
     MISIILVMIG GGFGAIARSA ITDYFNHKFT SKLPIATLIV NLVGSFLIGL TIGLSISISW
     FPAFFVTGFL GGLTTFSTLA KELTLMMTPK FNINLFLNYS LLQFIIGFIA CYIGYHI