ID   CRCB2_STRCO             Reviewed;         124 AA.
AC   Q9FC37;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Putative fluoride ion transporter CrcB 2 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB2 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=SCO7046;
GN   ORFNames=SC4G1.12;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AL939130; CAC01544.1; -; Genomic_DNA.
DR   RefSeq; NP_631108.1; NC_003888.3.
DR   RefSeq; WP_011031399.1; NZ_VNID01000012.1.
DR   AlphaFoldDB; Q9FC37; -.
DR   SMR; Q9FC37; -.
DR   STRING; 100226.SCO7046; -.
DR   GeneID; 1102484; -.
DR   KEGG; sco:SCO7046; -.
DR   PATRIC; fig|100226.15.peg.7150; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_2_1_11; -.
DR   InParanoid; Q9FC37; -.
DR   OMA; FLMFESF; -.
DR   PhylomeDB; Q9FC37; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
DR   TIGRFAMs; TIGR00494; crcB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..124
FT                   /note="Putative fluoride ion transporter CrcB 2"
FT                   /id="PRO_0000110193"
FT   TRANSMEM        2..19
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        63..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   124 AA;  12636 MW;  FFBCD2CA00081E6D CRC64;
     MNWLLVVAGG MIGAPLRYLT DRAVQSRHDS VFPWGTFTVN VIGSVVLGLL TGAALAGAVG
     SDLRLLLGTG LCGALTTYST FSYETLRLTE TGARLHAAVN VGGSVAAGLV AAFAGVTLAD
     ALWA