ID   CRCB3_BRUME             Reviewed;         137 AA.
AC   Q8YCQ9;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Putative fluoride ion transporter CrcB 3 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB3 {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=BMEII0469;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE008918; AAL53711.1; -; Genomic_DNA.
DR   PIR; AD3568; AD3568.
DR   RefSeq; WP_004684861.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YCQ9; -.
DR   SMR; Q8YCQ9; -.
DR   STRING; 224914.BMEII0469; -.
DR   EnsemblBacteria; AAL53711; AAL53711; BMEII0469.
DR   GeneID; 29595838; -.
DR   KEGG; bme:BMEII0469; -.
DR   KEGG; bmel:DK63_2771; -.
DR   PATRIC; fig|224914.52.peg.2901; -.
DR   eggNOG; COG0239; Bacteria.
DR   OMA; WQTILAV; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..137
FT                   /note="Putative fluoride ion transporter CrcB 3"
FT                   /id="PRO_0000110073"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   137 AA;  14671 MW;  684EF8E854910E8B CRC64;
     MRNWRQAENI RLYIAVGCGA AIGALLRFLS GWVIVAILGA NPLWGTSFVN IVGSFIIMFF
     ATLTGPEGRW LVSPALRQFV MGGLCGGLTT FSSMSLDTFL LVLHGNAAFA LAYLCGLVFL
     SLSAAMLGLI AAQRINR