ID   CRCB3_BRUSU             Reviewed;         133 AA.
AC   Q8FVM0; G0KDI0;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Putative fluoride ion transporter CrcB 3 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB3 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   OrderedLocusNames=BRA0817, BS1330_II0810;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AE014292; AAN33992.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM20268.1; -; Genomic_DNA.
DR   RefSeq; WP_004690316.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FVM0; -.
DR   SMR; Q8FVM0; -.
DR   EnsemblBacteria; AEM20268; AEM20268; BS1330_II0810.
DR   GeneID; 45053832; -.
DR   GeneID; 55592466; -.
DR   KEGG; bms:BRA0817; -.
DR   KEGG; bsi:BS1330_II0810; -.
DR   PATRIC; fig|204722.21.peg.3548; -.
DR   HOGENOM; CLU_114342_3_0_5; -.
DR   OMA; FPWATFW; -.
DR   PhylomeDB; Q8FVM0; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..133
FT                   /note="Putative fluoride ion transporter CrcB 3"
FT                   /id="PRO_0000110077"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   133 AA;  14024 MW;  38C92792DB8C63A5 CRC64;
     MSVEASILVL VGGFIGGVMR FFLSGYVGRR IGETFPWGTF VVNVSGAFVI GTAAGLGARL
     GAIFSTTIFH EFIMVGLLGG YTTVSSFCLQ SVNLMLDGEQ RQALFNIVAS ALLCVLAVAA
     GYGGIMWIME WPG