ID   CRCB4_BRUAB             Reviewed;         133 AA.
AC   Q578U0;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Putative fluoride ion transporter CrcB 4 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB4 {ECO:0000255|HAMAP-Rule:MF_00454};
GN   OrderedLocusNames=BruAb2_0415;
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=262698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941;
RX   PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA   Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison to
RT   the highly similar genomes of Brucella melitensis and Brucella suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AE017224; AAX75844.1; -; Genomic_DNA.
DR   RefSeq; WP_002965823.1; NC_006933.1.
DR   AlphaFoldDB; Q578U0; -.
DR   SMR; Q578U0; -.
DR   EnsemblBacteria; AAX75844; AAX75844; BruAb2_0415.
DR   GeneID; 45126144; -.
DR   KEGG; bmb:BruAb2_0415; -.
DR   HOGENOM; CLU_114342_3_0_5; -.
DR   OMA; FPWATFW; -.
DR   Proteomes; UP000000540; Chromosome II.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..133
FT                   /note="Putative fluoride ion transporter CrcB 4"
FT                   /id="PRO_0000110070"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   133 AA;  14010 MW;  D157200B458C63A0 CRC64;
     MSVEASILVL VGGFIGGVMR FFLSGYVGRR IGETFPWGTF VVNVSGAFVI GTAAGLGARL
     GGIFSTTIFH EFIMVGLLGG YTTVSSFCLQ SVNLMLDGEQ RQALFNIVAS ALLCVLAVAA
     GYGGIMWIME WPG