CRCB4_BRUSU
ID CRCB4_BRUSU Reviewed; 137 AA.
AC Q8FVL9; G0KDI1;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Putative fluoride ion transporter CrcB 4 {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB4 {ECO:0000255|HAMAP-Rule:MF_00454};
GN OrderedLocusNames=BRA0818, BS1330_II0811;
OS Brucella suis biovar 1 (strain 1330).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=204722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between animal
RT and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=22038969; DOI=10.1128/jb.06181-11;
RA Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT "Revised genome sequence of Brucella suis 1330.";
RL J. Bacteriol. 193:6410-6410(2011).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; AE014292; AAN33993.1; -; Genomic_DNA.
DR EMBL; CP002998; AEM20269.1; -; Genomic_DNA.
DR RefSeq; WP_002968948.1; NZ_KN046805.1.
DR AlphaFoldDB; Q8FVL9; -.
DR SMR; Q8FVL9; -.
DR EnsemblBacteria; AEM20269; AEM20269; BS1330_II0811.
DR GeneID; 45126145; -.
DR GeneID; 55592467; -.
DR KEGG; bms:BRA0818; -.
DR KEGG; bsi:BS1330_II0811; -.
DR PATRIC; fig|204722.21.peg.3549; -.
DR HOGENOM; CLU_114342_3_0_5; -.
DR OMA; FLMFESF; -.
DR Proteomes; UP000007104; Chromosome II.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..137
FT /note="Putative fluoride ion transporter CrcB 4"
FT /id="PRO_0000110078"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 137 AA; 14745 MW; 7C0AA8E8548A158B CRC64;
MRNWRQAENI RLYIAVGCGA AIGALLRFLS GWVIVAILGA NPLWGTSFVN IVGSFIIMFF
ATLTGPEGRW LVSPAWRQFV MGGLCGGLTT FSSMSLDTFL LVLHGNAAFA LAYLCGLVFL
SLSAAMLGLI AAQRINR
