ID   CRCB_BORPE              Reviewed;         128 AA.
AC   Q7VYU0;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=BP1217;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; BX640414; CAE41513.1; -; Genomic_DNA.
DR   RefSeq; NP_879990.1; NC_002929.2.
DR   RefSeq; WP_003818609.1; NZ_CP039022.1.
DR   PDB; 5A40; X-ray; 3.60 A; A/B/C/D=1-128.
DR   PDB; 5NKQ; X-ray; 2.17 A; A/B/C/D=1-128.
DR   PDB; 6BQO; X-ray; 2.80 A; A/B=1-128.
DR   PDBsum; 5A40; -.
DR   PDBsum; 5NKQ; -.
DR   PDBsum; 6BQO; -.
DR   AlphaFoldDB; Q7VYU0; -.
DR   SMR; Q7VYU0; -.
DR   DIP; DIP-61785N; -.
DR   STRING; 257313.BP1217; -.
DR   TCDB; 1.A.43.1.17; the camphor resistance or fluoride exporter (fluc) family.
DR   GeneID; 45388532; -.
DR   KEGG; bpe:BP1217; -.
DR   PATRIC; fig|257313.5.peg.1311; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_3_3_4; -.
DR   OMA; FLMFESF; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
DR   TIGRFAMs; TIGR00494; crcB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..128
FT                   /note="Putative fluoride ion transporter CrcB"
FT                   /id="PRO_0000110064"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   HELIX           6..30
FT                   /evidence="ECO:0007829|PDB:5NKQ"
FT   STRAND          33..36
FT                   /evidence="ECO:0007829|PDB:5NKQ"
FT   HELIX           37..59
FT                   /evidence="ECO:0007829|PDB:5NKQ"
FT   HELIX           65..71
FT                   /evidence="ECO:0007829|PDB:5NKQ"
FT   TURN            72..74
FT                   /evidence="ECO:0007829|PDB:5NKQ"
FT   HELIX           75..79
FT                   /evidence="ECO:0007829|PDB:5NKQ"
FT   HELIX           83..95
FT                   /evidence="ECO:0007829|PDB:5NKQ"
FT   HELIX           98..126
FT                   /evidence="ECO:0007829|PDB:5NKQ"
SQ   SEQUENCE   128 AA;  13339 MW;  9D5891AB203DE070 CRC64;
     MLTYAPLNFI AIGIGATLGA WLRWVLGLRL NGAGWPWGTL TANLVGGYLI GVMVALIASH
     PEWPAWIRLA AVTGFLGGLT TFSTFSAETV DMLERGVYAT AAAYAGASLA GSLAMTGLGL
     ATVRLLLR