ID   CRCB_CUPNH              Reviewed;         126 AA.
AC   Q8VM97; Q0K9G3;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB {ECO:0000255|HAMAP-Rule:MF_00454}; Synonyms=moaF;
GN   OrderedLocusNames=H16_A2261;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11545279;
RA   Burgdorf T., Bommer D., Bowien B.;
RT   "Involvement of an unusual mol operon in molybdopterin cofactor
RT   biosynthesis in Ralstonia eutropha.";
RL   J. Mol. Microbiol. Biotechnol. 3:619-629(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; AJ279073; CAC82490.1; -; Genomic_DNA.
DR   EMBL; AM260479; CAJ93358.1; -; Genomic_DNA.
DR   RefSeq; WP_010810480.1; NZ_CP039287.1.
DR   AlphaFoldDB; Q8VM97; -.
DR   SMR; Q8VM97; -.
DR   STRING; 381666.H16_A2261; -.
DR   EnsemblBacteria; CAJ93358; CAJ93358; H16_A2261.
DR   GeneID; 57644390; -.
DR   KEGG; reh:H16_A2261; -.
DR   eggNOG; COG0239; Bacteria.
DR   HOGENOM; CLU_114342_3_3_4; -.
DR   OMA; EWRLFLI; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
DR   TIGRFAMs; TIGR00494; crcB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..126
FT                   /note="Putative fluoride ion transporter CrcB"
FT                   /id="PRO_0000110035"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   126 AA;  13116 MW;  AC2FF345A6849C12 CRC64;
     MGPLGFVAVG VGAAAGAWLR WGFAVLWNAI NPALPYGTLA ANLLGGYLVG LAVGFFDTHA
     GLPPEWRLLA ITGFLGGLTT FSTFSSEVVA NLIAGDYGWA GLHLLLHLGG SLLLTAFGLW
     TYRLLA