CRCB_HAEIN
ID CRCB_HAEIN Reviewed; 160 AA.
AC P46491;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=HI_0597.1;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP IDENTIFICATION.
RA Koonin E.V., Rudd K.E.;
RL Submitted (SEP-1995) to UniProtKB.
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; L42023; AAC22255.1; -; Genomic_DNA.
DR RefSeq; NP_438755.1; NC_000907.1.
DR RefSeq; WP_010869016.1; NC_000907.1.
DR AlphaFoldDB; P46491; -.
DR SMR; P46491; -.
DR STRING; 71421.HI_0597.1; -.
DR EnsemblBacteria; AAC22255; AAC22255; HI_0597.1.
DR KEGG; hin:HI_0597.1; -.
DR PATRIC; fig|71421.8.peg.619; -.
DR eggNOG; COG0239; Bacteria.
DR HOGENOM; CLU_114342_3_3_6; -.
DR OMA; EWRLFLI; -.
DR PhylomeDB; P46491; -.
DR BioCyc; HINF71421:G1GJ1-608-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
DR TIGRFAMs; TIGR00494; crcB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..160
FT /note="Putative fluoride ion transporter CrcB"
FT /id="PRO_0000110108"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 160 AA; 18285 MW; D8A7EC5652C1D96A CRC64;
MQALLFISYG AILGASLRWA IGLLFNPLFS SFAFGTLIAN LFGCLIIGVL LGLFWQFPQI
SAEWRLFLIT GFLGSLTTFS SFSSEVVELF FNDKWLNGFC VLMMHLFGCL AMTVLGIWIY
KICLNFYLNP IHFGFAQLNQ QIHRYEIRVI AYIAKFFVSF
