ID   CRCB_METJA              Reviewed;         124 AA.
AC   Q58918;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000255|HAMAP-Rule:MF_00454};
GN   Name=crcB {ECO:0000255|HAMAP-Rule:MF_00454}; OrderedLocusNames=MJ1523;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC       thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00454};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454}.
CC   -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC       Rule:MF_00454}.
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DR   EMBL; L77117; AAB99542.1; -; Genomic_DNA.
DR   PIR; B64490; B64490.
DR   RefSeq; WP_010871047.1; NC_000909.1.
DR   AlphaFoldDB; Q58918; -.
DR   SMR; Q58918; -.
DR   STRING; 243232.MJ_1523; -.
DR   EnsemblBacteria; AAB99542; AAB99542; MJ_1523.
DR   GeneID; 1452431; -.
DR   KEGG; mja:MJ_1523; -.
DR   eggNOG; arCOG04701; Archaea.
DR   HOGENOM; CLU_114342_3_0_2; -.
DR   InParanoid; Q58918; -.
DR   OMA; FLMFESF; -.
DR   OrthoDB; 112898at2157; -.
DR   PhylomeDB; Q58918; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:1903425; F:fluoride transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR   HAMAP; MF_00454; CrcB; 1.
DR   InterPro; IPR003691; CrcB.
DR   PANTHER; PTHR28259; PTHR28259; 1.
DR   Pfam; PF02537; CRCB; 1.
DR   TIGRFAMs; TIGR00494; crcB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..124
FT                   /note="Putative fluoride ion transporter CrcB"
FT                   /id="PRO_0000110228"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ   SEQUENCE   124 AA;  13534 MW;  E5B702BC06104B9D CRC64;
     MIRELLLIGV GGFFGAIFRY LISGIVPVKF GLPTGTLAVN LIGSFILGFL LYCSLFAPIP
     TEYKLFIGTG FCGALTTFST FSYETFVLVD EGLLFKALLN ILINVVGCLI MVYFGRVLAL
     AIFR