CRCB_VIBC3
ID CRCB_VIBC3 Reviewed; 126 AA.
AC A5F4D3; C3M2I4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000255|HAMAP-Rule:MF_00454};
GN Name=crcB {ECO:0000255|HAMAP-Rule:MF_00454};
GN OrderedLocusNames=VC0395_A2453, VC395_0120;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000255|HAMAP-Rule:MF_00454}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-
CC Rule:MF_00454}.
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DR EMBL; CP000627; ABQ20911.1; -; Genomic_DNA.
DR EMBL; CP001235; ACP08148.1; -; Genomic_DNA.
DR RefSeq; WP_000006444.1; NZ_JAACZH010000014.1.
DR AlphaFoldDB; A5F4D3; -.
DR SMR; A5F4D3; -.
DR STRING; 345073.VC395_0120; -.
DR EnsemblBacteria; ABQ20911; ABQ20911; VC0395_A2453.
DR GeneID; 57741434; -.
DR KEGG; vco:VC0395_A2453; -.
DR KEGG; vcr:VC395_0120; -.
DR PATRIC; fig|345073.21.peg.111; -.
DR eggNOG; COG0239; Bacteria.
DR HOGENOM; CLU_114342_3_0_6; -.
DR OMA; EWRLFLI; -.
DR Proteomes; UP000000249; Chromosome 2.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR HAMAP; MF_00454; CrcB; 1.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 1.
DR TIGRFAMs; TIGR00494; crcB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..126
FT /note="Putative fluoride ion transporter CrcB"
FT /id="PRO_1000072380"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00454"
SQ SEQUENCE 126 AA; 13531 MW; 05766DF62CAA7F2E CRC64;
MSFAILGFIA LGGAVGACAR FLVSEICVTL FGRGFPIGTL TVNVVGSFIM GVLIACVENE
WLSPYPWKQV IGLGFLGALT TFSTFSMDNV LLMQQGAFFK MGANVLLNVI LSISAAWIGF
HWLMKS