CRCC2_HUMAN
ID CRCC2_HUMAN Reviewed; 1653 AA.
AC H7BZ55;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2019, sequence version 4.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Ciliary rootlet coiled-coil protein 2 {ECO:0000305};
GN Name=CROCC2 {ECO:0000312|HGNC:HGNC:51677};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- SIMILARITY: Belongs to the rootletin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC104809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H7BZ55; -.
DR SMR; H7BZ55; -.
DR IntAct; H7BZ55; 2.
DR STRING; 9606.ENSP00000397968; -.
DR PhosphoSitePlus; H7BZ55; -.
DR BioMuta; CROCC2; -.
DR jPOST; H7BZ55; -.
DR MassIVE; H7BZ55; -.
DR PaxDb; H7BZ55; -.
DR PeptideAtlas; H7BZ55; -.
DR PRIDE; H7BZ55; -.
DR Antibodypedia; 62332; 3 antibodies from 3 providers.
DR Ensembl; ENST00000690015.1; ENSP00000508848.1; ENSG00000226321.6.
DR MANE-Select; ENST00000690015.1; ENSP00000508848.1; NM_001351305.2; NP_001338234.1.
DR GeneCards; CROCC2; -.
DR HGNC; HGNC:51677; CROCC2.
DR HPA; ENSG00000226321; Tissue enhanced (choroid plexus, fallopian tube).
DR neXtProt; NX_H7BZ55; -.
DR OpenTargets; ENSG00000226321; -.
DR VEuPathDB; HostDB:ENSG00000226321; -.
DR eggNOG; ENOG502QQV3; Eukaryota.
DR GeneTree; ENSGT00940000162689; -.
DR HOGENOM; CLU_000920_1_0_1; -.
DR InParanoid; H7BZ55; -.
DR PathwayCommons; H7BZ55; -.
DR SignaLink; H7BZ55; -.
DR ChiTaRS; CROCC2; human.
DR Pharos; H7BZ55; Tdark.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; H7BZ55; protein.
DR Bgee; ENSG00000226321; Expressed in right uterine tube and 80 other tissues.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..1653
FT /note="Ciliary rootlet coiled-coil protein 2"
FT /id="PRO_0000422613"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1302..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..145
FT /evidence="ECO:0000255"
FT COILED 310..351
FT /evidence="ECO:0000255"
FT COILED 423..1215
FT /evidence="ECO:0000255"
FT COILED 1361..1570
FT /evidence="ECO:0000255"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1653 AA; 185641 MW; BE6A4A0296654CD7 CRC64;
MSSASSEPGN GDASQQPLLG LDTVIQRLED TILSPTASRE DRALTVRGEG RQASPTPVPT
RIREIVAGSL SEEPPQAGVQ EPTATVARVQ EENELLQEEL TRLGDLLAQA SAERDELASR
CRVVSEQLQA RLETTEAQLR RSELEHSVDL EEALGRLEAA EERSTGLCQV NALLREQLEH
MKKANDALGR ELAGMTGSVQ RLQGELELRR WAQRQTRSGG LGQPRDLLLL WRQAVVLGTD
LAELRVATER GLADLQADTA RTARRLHTAC LNLDSNLRLS ASSTASTLGQ QLRDKAGEML
QLQGRWDAEK VALQARLSEQ TLLVEKLTEQ NEQKAKTIAA LRTDLQNLVA QEDARCLELA
GSSITELGEP RRPLRSPQRA TSPHQGASPP HICSPATLDP ALQAMRAAIE RRWRREQELC
LQLKSSQALV ASLQEQLSES RRELWAAQKL QQERAREQAR EREALRGQLE AQRLEVQQCR
ASCKLLGREK AALEMVVEEL KGKADAADAE KQGLEAEAAE LQRSLLLQAE RREELALRRE
RSCRALETSQ GRLQQLEEKV SGLREELASV REALSTAQLQ RDVVESEREG LRSALARAEC
SNADLELLVR RLKSEGVEQR DSLAAMAALM EGLAQDKSAL NHLALQLEQE RDQLREQRKT
LEQERARAGE QLAQAEQQLA LERAERRGLQ QACGRLEQRQ EQLEGQAALL GREKAQLQEQ
VGQVTCQKQA LEEQLAQSLQ DQEAQMGTLQ QALQGKDALS EERAQLLAKQ EALERQGRLA
AEEAADLRVE RDSLESSLLE AQQLATKLQE QLEEEARSAG LARQALQVEM EQLQSDWEVQ
EMKLRQDTVR LQRQVAQQER EAQRALESQA LAHREALAQL QREKETLSLT LAEEKEVARC
QLEQEKELVT KSAAEREALK GEIQSLKQER DESLLQLEHK MQQALSLKET ERSLLSEELS
RARRTLERVQ QEAQSQQEQA QATISATTEE LKALQAQFED AITAHQRETT ALRESLQDLA
AERGDVEREA ERLRAQLTVA QEGLAALRQE LQGVEESREG LHREAQEARR ALSDEAREKD
VLLLFNSELR ATICRAEQEK ASFKRSKEEK EQKLLILEEA QAALQQEASA LRAHLWELEQ
AGGDARQELR ELHRQVRTLK AENQRRSGEA HELQAQCSQE VLELRRQAAK AEAKHEGARK
EVLGLQRKLA EVEAAGEAHG QRLQEHLRES RGAEQTLRAE LHSVTRKLQE ASGVADALQA
RLDQACHRIH SLEQELAQAE GARQDAEAQL GRLCSTLRRG LGLQRQSPWA SPEQPGSPTK
GSDSSQALPG QQGTSPPARP HSPLRWPSPT PGGRSSELMD VATVQDILRD FVQKLREAQR
ERDDSRIQMA TLSSRLSEAE CRCARAQSRV GQLQKALAEA EEGQRRVEGA LSSARAARAL
QKEALRRLEL EHLASVRAAG QEKRRLQEQL ETLRQALEES RRHSQGLAKQ GKLLEEQLTN
LEHRCQKAEV SLEPLRQMEQ ETLKREEDVA RLGAEKEQLD QSLNSLHQEV DGALRQNQQL
QAQMTEMEQA HTQRLQDLTA QHQRDLATEA ERLHGARPQA TQALESQEWT HQQQVKVLEE
QVASLKEQLD QEVQWRQQAH LGQAFQTGHA QRD
