ID   CRCC2_MOUSE             Reviewed;        1638 AA.
AC   F6XLV1;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Ciliary rootlet coiled-coil protein 2 {ECO:0000305};
GN   Name=Crocc2 {ECO:0000312|MGI:MGI:3045962};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SIMILARITY: Belongs to the rootletin family. {ECO:0000305}.
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DR   EMBL; AC103673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC124669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS78654.1; -.
DR   RefSeq; NP_001297357.1; NM_001310428.1.
DR   AlphaFoldDB; F6XLV1; -.
DR   SMR; F6XLV1; -.
DR   STRING; 10090.ENSMUSP00000120588; -.
DR   PhosphoSitePlus; F6XLV1; -.
DR   PaxDb; F6XLV1; -.
DR   PRIDE; F6XLV1; -.
DR   ProteomicsDB; 373562; -.
DR   Antibodypedia; 62332; 3 antibodies from 3 providers.
DR   Ensembl; ENSMUST00000138595; ENSMUSP00000120588; ENSMUSG00000084989.
DR   GeneID; 381284; -.
DR   KEGG; mmu:381284; -.
DR   CTD; 728763; -.
DR   MGI; MGI:3045962; Crocc2.
DR   VEuPathDB; HostDB:ENSMUSG00000084989; -.
DR   eggNOG; ENOG502QQV3; Eukaryota.
DR   GeneTree; ENSGT00940000162689; -.
DR   HOGENOM; CLU_000920_1_0_1; -.
DR   InParanoid; F6XLV1; -.
DR   OMA; RGLQQAC; -.
DR   OrthoDB; 76868at2759; -.
DR   BioGRID-ORCS; 381284; 0 hits in 34 CRISPR screens.
DR   ChiTaRS; Crocc2; mouse.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; F6XLV1; protein.
DR   Bgee; ENSMUSG00000084989; Expressed in mesenchyme and 24 other tissues.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..1638
FT                   /note="Ciliary rootlet coiled-coil protein 2"
FT                   /id="PRO_0000452751"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1168..1213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1338..1383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1506..1551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          85..144
FT                   /evidence="ECO:0000255"
FT   COILED          426..1234
FT                   /evidence="ECO:0000255"
FT   COILED          1281..1315
FT                   /evidence="ECO:0000255"
FT   COILED          1412..1506
FT                   /evidence="ECO:0000255"
FT   COILED          1542..1576
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        405..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1168..1196
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1338..1371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1532..1551
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1638 AA;  186631 MW;  2477189C6D423D93 CRC64;
     MSSTSSNPDD GDTTEQSQLG LDTVIKKLED TILSPMARRE DRALTVRGEG QRASPTPVPA
     RIREIVSSSL GEEPLSGLRE PPATTSHARE ESELLQEELT RLEDLLAQAD AEREELASRC
     HMVSQRLQAR LDTTEARLRK SELEHSMDLE EALSRLEASQ QRSMGLSQVN TLLRQQLEHM
     QKANDTLARE LTRATHSLVH LQRKLELQES QRLSLRQPRD ILPLWRQAKA LQTHLAELRA
     STERGLTDVQ ADMTRTAQRL HMACLNLDSH LRLTASSMTS DLEQRLREQA REMLQLQGQW
     AAEKVALQAR LSEQTLLVEK LSVQKEQGER AILTLKSDIQ RLKSRRSGGQ LAVDELRDEV
     ESLHHVLASI KEVAQSDAMC PELAWSSSIE VREAQARLRS PPRSVSPHQR MSPARTSSPT
     SLHPALQAVQ AAIERRQQRE QELRLRLESS QEEAAGLREQ LSGYRQELRT SQRLLQDRAQ
     EHEDLLGQLE AQRQEAQLSQ ASVHLLEREK EALETTMEEL RAKADIREAE TQKLEVTNAE
     LRRSLLLRAE QKAELAQQSE RSLRELEASQ GRVEQLEEKV SGLRKELATS REALSSMQLQ
     RDILETEKES LHGALAQAES GNADLELLVT RLKAEGMEQQ DSLAKMAALL EGLSQDKGTL
     NHLALQLEQE RDQLREQQKM LQQEQAGMRE QLTQTGQQLG LIRAERRSLK ETCGHLEQKQ
     DHLEKQVVLL GQENAQLREQ VGQVTNKKQA LEKQLAQSLQ DQEAQMDILQ EALHEKNTLS
     EERAQLLAKQ EALERHSELV TKEAADLRAE RNSLENSLFE AQRLTTQLQT QQEQLEGKAE
     AAQLARRALQ VEIERLKSDW EVRETKLQLH LGQLQQQAAQ QEQEAQLALE RQELAHTEDL
     ARLHREKDTL SLSLAEEKEA AARWMEQQKE LLTRSAADRE ALQGEIQNLK QERDESLLQL
     EHEMQQALSL KDAEKSLLSK ELSGAHRELE RARQEAQNQQ VQAEATVTTM TKELRTLQVQ
     FEEAISTHQR EADTLREKLR EIAAERSSVR REAEELQAQL NVAHERLAEL RQELQASEES
     REGLQREALG ARRALEDEVQ EKDVLQHSNT ELRASIHRAE QEKASLKRSK EEQEQKLLLL
     QEAQVAAQKE AYELRTRLQE LERAQRDTRR KLQERHRQVR TLEAENQRKR QEVSDLQAQV
     SRDAQHRQKN LQESLELQRQ VAEAQAAHDG VQKEVLGLRQ KLAEVEASGE TRAKQLEGHL
     CESQRAEQTL QAELCRITRK LQEASNQADS LQRSLDNACS RVHVLEQELA KAEGARCNAE
     AQLGRLWSTL CSGLGQSRNL LASPKRPHSP TTGSSQTRPG RQRTSPPTRS YSPARWPSPV
     PVDPKSEVID VAFVRDALRD LVQGLLEAQQ ERDNSGIQVA NLSSQLSEAE RERLRLQSRV
     EQLQRDLADA EEGQRRAESA LQSAQAARAL QKEALQRLET EHLASARAAG QERRRLQEQV
     DTLRQALEES SRPSQSLADK GRLLEQPLQQ VLPHSRRDRA ERRALREQTT SLRTERARLQ
     GELAALRTRL IQTEQETLKK EEDRAMLGAK KELLLQSLSH LHQEVDGALR QSQQLQVASL
     KKRLDKEVWQ RQQQAHSD