CRCDL_HUMAN
ID CRCDL_HUMAN Reviewed; 962 AA.
AC Q6NV74;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=CRACD-like protein {ECO:0000305};
GN Name=CRACDL {ECO:0000312|HGNC:HGNC:33454};
GN Synonyms=C2orf55 {ECO:0000312|HGNC:HGNC:33454},
GN KIAA1211L {ECO:0000312|HGNC:HGNC:33454};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92 AND SER-490, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH68277.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC084377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC068277; AAH68277.1; ALT_FRAME; mRNA.
DR CCDS; CCDS42720.1; -.
DR RefSeq; NP_997245.2; NM_207362.2.
DR AlphaFoldDB; Q6NV74; -.
DR SMR; Q6NV74; -.
DR BioGRID; 131284; 5.
DR IntAct; Q6NV74; 4.
DR STRING; 9606.ENSP00000380996; -.
DR iPTMnet; Q6NV74; -.
DR PhosphoSitePlus; Q6NV74; -.
DR BioMuta; KIAA1211L; -.
DR DMDM; 215274155; -.
DR EPD; Q6NV74; -.
DR jPOST; Q6NV74; -.
DR MassIVE; Q6NV74; -.
DR MaxQB; Q6NV74; -.
DR PaxDb; Q6NV74; -.
DR PeptideAtlas; Q6NV74; -.
DR PRIDE; Q6NV74; -.
DR ProteomicsDB; 66714; -.
DR Antibodypedia; 47517; 65 antibodies from 14 providers.
DR DNASU; 343990; -.
DR Ensembl; ENST00000397899.7; ENSP00000380996.2; ENSG00000196872.12.
DR GeneID; 343990; -.
DR KEGG; hsa:343990; -.
DR MANE-Select; ENST00000397899.7; ENSP00000380996.2; NM_207362.3; NP_997245.2.
DR UCSC; uc002szf.2; human.
DR CTD; 343990; -.
DR DisGeNET; 343990; -.
DR GeneCards; CRACDL; -.
DR HGNC; HGNC:33454; CRACDL.
DR HPA; ENSG00000196872; Tissue enhanced (brain, epididymis).
DR neXtProt; NX_Q6NV74; -.
DR OpenTargets; ENSG00000196872; -.
DR PharmGKB; PA31767; -.
DR VEuPathDB; HostDB:ENSG00000196872; -.
DR eggNOG; ENOG502QSVM; Eukaryota.
DR GeneTree; ENSGT00940000161984; -.
DR HOGENOM; CLU_311439_0_0_1; -.
DR InParanoid; Q6NV74; -.
DR OMA; SLKYREG; -.
DR OrthoDB; 1409048at2759; -.
DR PhylomeDB; Q6NV74; -.
DR TreeFam; TF335584; -.
DR PathwayCommons; Q6NV74; -.
DR SignaLink; Q6NV74; -.
DR BioGRID-ORCS; 343990; 11 hits in 1067 CRISPR screens.
DR ChiTaRS; KIAA1211L; human.
DR GenomeRNAi; 343990; -.
DR Pharos; Q6NV74; Tdark.
DR PRO; PR:Q6NV74; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6NV74; protein.
DR Bgee; ENSG00000196872; Expressed in bronchial epithelial cell and 179 other tissues.
DR ExpressionAtlas; Q6NV74; baseline and differential.
DR Genevisible; Q6NV74; HS.
DR InterPro; IPR026713; CRACD-like.
DR InterPro; IPR028030; DUF4592.
DR PANTHER; PTHR47743; PTHR47743; 1.
DR Pfam; PF15262; DUF4592; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..962
FT /note="CRACD-like protein"
FT /id="PRO_0000289161"
FT REGION 38..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..303
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..365
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..453
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..805
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 490
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 315
FT /note="S -> C (in dbSNP:rs3731660)"
FT /id="VAR_047335"
FT CONFLICT 509
FT /note="P -> T (in Ref. 2; AAH68277)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 962 AA; 102157 MW; AC2C9BFE1C41DB98 CRC64;
MISTRVMDIK LREAAEGLGE DSTGKKKSKF KTFKKFFGKK KRKESPSSTG SSTWKQSQTR
NEVIAIESGP VGYDSEDELE ESRGTLGSRA LSHDSIFIPE SGQDATRPVR VFSQENVCDR
IKALQLKIQC NVKMGPPPPP GGLPAKRGED AGMSSEDDGL PRSPPEMSLL HDVGPGTTIK
VSVVSPDHVS DSTVSARISD NSLAPVADFS YPAESSSCLD NSAAKHKLQV KPRNQRSSKM
RRLSSRAQSE SLSDLTCTPE EEENEEKPLL EVSPEERPSS GQQDVAPDRG PEPGPPAPLP
PPGGARARRA RLQHSSALTA SVEEGGVPGE DPSSRPATPE LAEPESAPTL RVEPPSPPEG
PPNPGPDGGK QDGEAPPAGP CAPATDKAEE VVCAPEDVAS PFPTAIPEGD TTPPETDPAA
TSEAPSARDG PERSVPKEAE PTPPVLPDEE KGPPGPAPEP EREAETEPER GAGTEPERIG
TEPSTAPAPS PPAPKSCLKH RPAAASEGPA ASPPLAAAES PPVEPGPGSL DAEAAAPERP
KAERAEAPPA GAERAAPERK AERGGAELRG AKKFSVSSCR ARPRPGVSRP LERASGRLPL
ARSGPVWRSE AALDDLQGLP EPQHAKPGPR KLAERGPQDS GDRAASPAGP RKSPQEAAAA
PGTREPCPAA QEPAPSEDRN PFPVKLRSTS LSLKYRDGAS QEVKGVKRYS AEVRLERSLT
VLPKEEKCPL GTAPALRGTR APSDQGKGKA RPPEPLSSKP PLPRKPLLQS FTLPHQPAPP
DAGPGEREPR KEPRTAEKRP LRRGAEKSLP PAATGPGADG QPAPPWITVT RQKRRGTLDQ
PPNQEDKPGA RTLKSEPGKQ AKVPERGQEP VKQADFVRSK SFLITPVKPA VDRKQGAKLN
FKEGLQRGIS LSHQNLAQSA VMMEKELHQL KRASYASTDQ PSWMELARKK SQAWSDMPQI
IK
