ID   CRCM1_CHICK             Reviewed;         226 AA.
AC   Q5ZL05;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Calcium release-activated calcium channel protein 1;
DE   AltName: Full=Protein orai-1;
DE   AltName: Full=Transmembrane protein 142A;
GN   Name=ORAI1; Synonyms=CRACM1, TMEM142A; ORFNames=RCJMB04_8f15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which
CC       mediates Ca(2+) influx following depletion of intracellular Ca(2+)
CC       stores. {ECO:0000250|UniProtKB:Q96D31}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D31};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96D31}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR   EMBL; AJ719929; CAG31588.1; -; mRNA.
DR   RefSeq; NP_001025829.1; NM_001030658.1.
DR   AlphaFoldDB; Q5ZL05; -.
DR   SMR; Q5ZL05; -.
DR   STRING; 9031.ENSGALP00000006734; -.
DR   PaxDb; Q5ZL05; -.
DR   GeneID; 416845; -.
DR   KEGG; gga:416845; -.
DR   CTD; 84876; -.
DR   VEuPathDB; HostDB:geneid_416845; -.
DR   eggNOG; KOG4298; Eukaryota.
DR   InParanoid; Q5ZL05; -.
DR   OrthoDB; 1197243at2759; -.
DR   PhylomeDB; Q5ZL05; -.
DR   PRO; PR:Q5ZL05; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015279; F:store-operated calcium channel activity; ISS:UniProtKB.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
DR   GO; GO:0002115; P:store-operated calcium entry; ISS:UniProtKB.
DR   Gene3D; 1.20.140.140; -; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; PTHR31501; 1.
DR   Pfam; PF07856; Orai-1; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Calcium; Calcium channel; Calcium transport;
KW   Cell membrane; Glycoprotein; Immunity; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..226
FT                   /note="Calcium release-activated calcium channel protein 1"
FT                   /id="PRO_0000234384"
FT   TOPO_DOM        1..56
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..110
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  25130 MW;  54B8C571B58DB801 CRC64;
     MSLNEHSMQA LSWRKLYLSR AKLKASSRTS ALLSGFAMVA MVEVQLDAEH DYPRGLLIAF
     SACTTVLVAV HLFALMISTC ILPNIEAVSN VHNLNSVKES PHERMHRHIE LAWAFSTVIG
     TLLFLAEVVL LCWVKFLPLK KNPLDPAENS NSSITSGQAA AIASTSIMVP FGLIFIVFAV
     HFYRSLVSHK TDRQFQELNE LAEFAWLQDQ LDHRGDAISP AVTHFA