ID   CRCM1_DANRE             Reviewed;         222 AA.
AC   Q6TLE6; Q504L0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Calcium release-activated calcium channel protein 1;
DE   AltName: Full=Protein orai-1;
DE   AltName: Full=Transmembrane protein 142A;
GN   Name=orai1; Synonyms=tmem142a; ORFNames=zgc:109721;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which
CC       mediates Ca(2+) influx following depletion of intracellular Ca(2+)
CC       stores. {ECO:0000250|UniProtKB:Q96D31}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D31};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96D31}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR   EMBL; AY394960; AAQ94587.1; -; mRNA.
DR   EMBL; BC094965; AAH94965.1; -; mRNA.
DR   RefSeq; NP_991163.1; NM_205600.1.
DR   AlphaFoldDB; Q6TLE6; -.
DR   SMR; Q6TLE6; -.
DR   STRING; 7955.ENSDARP00000022726; -.
DR   PaxDb; Q6TLE6; -.
DR   GeneID; 402892; -.
DR   KEGG; dre:402892; -.
DR   CTD; 402892; -.
DR   ZFIN; ZDB-GENE-050522-100; orai1b.
DR   eggNOG; KOG4298; Eukaryota.
DR   InParanoid; Q6TLE6; -.
DR   OrthoDB; 1197243at2759; -.
DR   PhylomeDB; Q6TLE6; -.
DR   TreeFam; TF313576; -.
DR   PRO; PR:Q6TLE6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015279; F:store-operated calcium channel activity; ISS:UniProtKB.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
DR   GO; GO:0045214; P:sarcomere organization; IMP:ZFIN.
DR   GO; GO:0002115; P:store-operated calcium entry; ISS:UniProtKB.
DR   Gene3D; 1.20.140.140; -; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; PTHR31501; 1.
DR   Pfam; PF07856; Orai-1; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Calcium; Calcium channel; Calcium transport;
KW   Cell membrane; Glycoprotein; Immunity; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..222
FT                   /note="Calcium release-activated calcium channel protein 1"
FT                   /id="PRO_0000234385"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..58
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..112
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..154
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        129
FT                   /note="G -> E (in Ref. 1; AAQ94587)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        145
FT                   /note="G -> D (in Ref. 1; AAQ94587)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   222 AA;  24633 MW;  A5B735B035D78894 CRC64;
     MKMSRSEHSL QALSWRKLYL SRAKLKASSR TSALLSGFAM VAMVEVQLDT NHDYPPGLLI
     AFSACTTVLV AVHLFALMVS TCILPNIEAV SNVHNLNSVK ESPHERMHRH IELAWAFSTV
     IGTLLFLAGV VLLCWVKFLP IKPKGQKNGT VSAGVAAAIT STSIMVPFGL VFIVFAVHFY
     RSLVSHKTDR QFQELEELED LQNELDHREE VSTLQSPGSL YP