ID   CRCM1_XENLA             Reviewed;         258 AA.
AC   Q5EAU0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Calcium release-activated calcium channel protein 1;
DE   AltName: Full=Protein orai-1;
DE   AltName: Full=Transmembrane protein 142A;
GN   Name=orai1; Synonyms=tmem142a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which
CC       mediates Ca(2+) influx following depletion of intracellular Ca(2+)
CC       stores. {ECO:0000250|UniProtKB:Q96D31}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D31};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96D31}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR   EMBL; BC090244; AAH90244.1; -; mRNA.
DR   EMBL; BC097707; AAH97707.1; -; mRNA.
DR   RefSeq; NP_001089486.1; NM_001096017.1.
DR   AlphaFoldDB; Q5EAU0; -.
DR   SMR; Q5EAU0; -.
DR   DNASU; 734537; -.
DR   GeneID; 734537; -.
DR   KEGG; xla:734537; -.
DR   CTD; 734537; -.
DR   Xenbase; XB-GENE-5781724; orai2.S.
DR   OMA; YTIMEDA; -.
DR   OrthoDB; 1197243at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 734537; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015279; F:store-operated calcium channel activity; ISS:UniProtKB.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
DR   GO; GO:0002115; P:store-operated calcium entry; ISS:UniProtKB.
DR   Gene3D; 1.20.140.140; -; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; PTHR31501; 1.
DR   Pfam; PF07856; Orai-1; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Calcium; Calcium channel; Calcium transport;
KW   Cell membrane; Glycoprotein; Immunity; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..258
FT                   /note="Calcium release-activated calcium channel protein 1"
FT                   /id="PRO_0000234386"
FT   TOPO_DOM        1..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..258
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        182
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   258 AA;  28737 MW;  E56D2B7C18CA1855 CRC64;
     MYPECGVETK SRPCSKQLQE EVSYPEWISR SYVELMSLNE HSMQALSWRK LYLSRAKLKA
     SSRTSALLSG FAMVAMVEVQ LEPNHAYPPG LLIAFSACTT VLVAVHLFAL MVSTCILPNI
     EAVSNVHNLN SVKESPHERM HHHIELAWAF STVIGTLLFL AEVVLLCWVK FLPVNSPKIS
     SNETSAVSSG QAAAITSTAI MVPFGLVFIV FAVHFYRSLV SHKTDRQFQE LNELAELAQL
     QDQLDHRGDP VQSPVHYA