CRCT1_HUMAN
ID CRCT1_HUMAN Reviewed; 99 AA.
AC Q9UGL9; A4QN00; Q6IAD7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Cysteine-rich C-terminal protein 1;
DE AltName: Full=Protein NICE-1;
GN Name=CRCT1; Synonyms=C1orf42, NICE1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Keratinocyte;
RX PubMed=11230159; DOI=10.1101/gr.114801;
RA Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A.,
RA Mischke D.;
RT "Identification of human epidermal differentiation complex (EDC)-encoded
RT genes by subtractive hybridization of entire YACs to a gridded keratinocyte
RT cDNA library.";
RL Genome Res. 11:341-355(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9UGL9; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-713677, EBI-741181;
CC Q9UGL9; P05187: ALPP; NbExp=3; IntAct=EBI-713677, EBI-1211484;
CC Q9UGL9; P55212: CASP6; NbExp=3; IntAct=EBI-713677, EBI-718729;
CC Q9UGL9; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-713677, EBI-14156412;
CC Q9UGL9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-713677, EBI-3867333;
CC Q9UGL9; P28799: GRN; NbExp=3; IntAct=EBI-713677, EBI-747754;
CC Q9UGL9; P05412: JUN; NbExp=3; IntAct=EBI-713677, EBI-852823;
CC Q9UGL9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-713677, EBI-11749135;
CC Q9UGL9; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-713677, EBI-10172290;
CC Q9UGL9; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-713677, EBI-10171774;
CC Q9UGL9; P60411: KRTAP10-9; NbExp=8; IntAct=EBI-713677, EBI-10172052;
CC Q9UGL9; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-713677, EBI-11953334;
CC Q9UGL9; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-713677, EBI-11957260;
CC Q9UGL9; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-713677, EBI-10302392;
CC Q9UGL9; Q9BQ66: KRTAP4-12; NbExp=7; IntAct=EBI-713677, EBI-739863;
CC Q9UGL9; Q9BYR5: KRTAP4-2; NbExp=7; IntAct=EBI-713677, EBI-10172511;
CC Q9UGL9; Q9BYR3: KRTAP4-4; NbExp=5; IntAct=EBI-713677, EBI-11958132;
CC Q9UGL9; Q9BYR2: KRTAP4-5; NbExp=4; IntAct=EBI-713677, EBI-11993254;
CC Q9UGL9; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-713677, EBI-11993296;
CC Q9UGL9; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-713677, EBI-11958178;
CC Q9UGL9; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-713677, EBI-11974251;
CC Q9UGL9; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-713677, EBI-11963072;
CC Q9UGL9; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-713677, EBI-10250562;
CC Q9UGL9; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-713677, EBI-11987425;
CC Q9UGL9; O75690: KRTAP5-8; NbExp=3; IntAct=EBI-713677, EBI-12134621;
CC Q9UGL9; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-713677, EBI-3958099;
CC Q9UGL9; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-713677, EBI-1044640;
CC Q9UGL9; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-713677, EBI-1043191;
CC Q9UGL9; P13473-2: LAMP2; NbExp=3; IntAct=EBI-713677, EBI-21591415;
CC Q9UGL9; Q5T751: LCE1C; NbExp=3; IntAct=EBI-713677, EBI-12224199;
CC Q9UGL9; Q5T754: LCE1F; NbExp=3; IntAct=EBI-713677, EBI-11958008;
CC Q9UGL9; O14633: LCE2B; NbExp=3; IntAct=EBI-713677, EBI-11478468;
CC Q9UGL9; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-713677, EBI-11973993;
CC Q9UGL9; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-713677, EBI-10246358;
CC Q9UGL9; Q14114-3: LRP8; NbExp=3; IntAct=EBI-713677, EBI-25832196;
CC Q9UGL9; Q8N5G2: MACO1; NbExp=5; IntAct=EBI-713677, EBI-2683507;
CC Q9UGL9; P50222: MEOX2; NbExp=4; IntAct=EBI-713677, EBI-748397;
CC Q9UGL9; Q7Z3S9: NOTCH2NLA; NbExp=5; IntAct=EBI-713677, EBI-945833;
CC Q9UGL9; P37198: NUP62; NbExp=6; IntAct=EBI-713677, EBI-347978;
CC Q9UGL9; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-713677, EBI-10277776;
CC Q9UGL9; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-713677, EBI-769257;
CC Q9UGL9; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-713677, EBI-5280197;
CC Q9UGL9; P62826: RAN; NbExp=3; IntAct=EBI-713677, EBI-286642;
CC Q9UGL9; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-713677, EBI-3918154;
CC Q9UGL9; O76081: RGS20; NbExp=3; IntAct=EBI-713677, EBI-1052678;
CC Q9UGL9; O76081-6: RGS20; NbExp=6; IntAct=EBI-713677, EBI-10178530;
CC Q9UGL9; P04271: S100B; NbExp=3; IntAct=EBI-713677, EBI-458391;
CC Q9UGL9; Q9H190: SDCBP2; NbExp=3; IntAct=EBI-713677, EBI-742426;
CC Q9UGL9; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-713677, EBI-2623095;
CC Q9UGL9; Q92504: SLC39A7; NbExp=3; IntAct=EBI-713677, EBI-1051105;
CC Q9UGL9; P43405-2: SYK; NbExp=3; IntAct=EBI-713677, EBI-25892332;
CC Q9UGL9; P22735: TGM1; NbExp=3; IntAct=EBI-713677, EBI-2562368;
CC Q9UGL9; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-713677, EBI-11747707;
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DR EMBL; AJ243662; CAB65093.1; -; mRNA.
DR EMBL; CR457218; CAG33499.1; -; mRNA.
DR EMBL; AL135842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53379.1; -; Genomic_DNA.
DR EMBL; BC119710; AAI19711.1; -; mRNA.
DR CCDS; CCDS1012.1; -.
DR RefSeq; NP_061933.1; NM_019060.2.
DR RefSeq; XP_011507958.1; XM_011509656.2.
DR AlphaFoldDB; Q9UGL9; -.
DR BioGRID; 120031; 57.
DR IntAct; Q9UGL9; 62.
DR STRING; 9606.ENSP00000357779; -.
DR BioMuta; CRCT1; -.
DR MassIVE; Q9UGL9; -.
DR PaxDb; Q9UGL9; -.
DR PeptideAtlas; Q9UGL9; -.
DR PRIDE; Q9UGL9; -.
DR ProteomicsDB; 84233; -.
DR Antibodypedia; 53893; 82 antibodies from 12 providers.
DR DNASU; 54544; -.
DR Ensembl; ENST00000368790.4; ENSP00000357779.3; ENSG00000169509.6.
DR GeneID; 54544; -.
DR KEGG; hsa:54544; -.
DR MANE-Select; ENST00000368790.4; ENSP00000357779.3; NM_019060.3; NP_061933.1.
DR UCSC; uc001ezz.4; human.
DR CTD; 54544; -.
DR DisGeNET; 54544; -.
DR GeneCards; CRCT1; -.
DR HGNC; HGNC:29875; CRCT1.
DR HPA; ENSG00000169509; Group enriched (esophagus, vagina).
DR MIM; 617426; gene.
DR neXtProt; NX_Q9UGL9; -.
DR OpenTargets; ENSG00000169509; -.
DR PharmGKB; PA162382812; -.
DR VEuPathDB; HostDB:ENSG00000169509; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00730000113097; -.
DR HOGENOM; CLU_2305176_0_0_1; -.
DR OMA; GSQRSQC; -.
DR PathwayCommons; Q9UGL9; -.
DR SignaLink; Q9UGL9; -.
DR BioGRID-ORCS; 54544; 230 hits in 1059 CRISPR screens.
DR ChiTaRS; CRCT1; human.
DR GenomeRNAi; 54544; -.
DR Pharos; Q9UGL9; Tbio.
DR PRO; PR:Q9UGL9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9UGL9; protein.
DR Bgee; ENSG00000169509; Expressed in lower esophagus mucosa and 104 other tissues.
DR Genevisible; Q9UGL9; HS.
DR InterPro; IPR031698; NICE-1.
DR Pfam; PF15845; NICE-1; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..99
FT /note="Cysteine-rich C-terminal protein 1"
FT /id="PRO_0000096812"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 96
FT /note="C -> Y (in dbSNP:rs16834168)"
FT /id="VAR_050906"
SQ SEQUENCE 99 AA; 9736 MW; B522D8E206305FDB CRC64;
MSSQQSAVSA KGFSKGSSQG PAPCPAPAPT PAPASSSSCC GSGRGCCGDS GCCGSSSTSC
CCFPRRRRRQ RSSGCCCCGG GSQRSQRSNN RSSGCCSGC
