CRD1_GOSHI
ID CRD1_GOSHI Reviewed; 405 AA.
AC Q6SJV8;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic;
DE Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE EC=1.14.13.81;
DE Flags: Precursor;
GN Name=CRD1; Synonyms=ZIP;
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hua X., Liu N., Liu H., Yang Y., Shan D., Zhang Y., Guo Y., Zhang M.,
RA Wu C., Li X., Zheng C.;
RT "Cloning and characterization of GhZIP.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the formation of the isocyclic ring in chlorophyll
CC biosynthesis. Mediates the cyclase reaction, which results in the
CC formation of divinylprotochlorophyllide (Pchlide) characteristic of all
CC chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester
CC (MgPMME) (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH +
CC 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+);
CC Xref=Rhea:RHEA:33235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:58632, ChEBI:CHEBI:60491; EC=1.14.13.81;
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the AcsF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAR20445.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY456957; AAR20445.2; ALT_INIT; mRNA.
DR AlphaFoldDB; Q6SJV8; -.
DR STRING; 3635.Q6SJV8; -.
DR PRIDE; Q6SJV8; -.
DR UniPathway; UPA00668; -.
DR Proteomes; UP000189702; Genome assembly.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IBA:GO_Central.
DR GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IBA:GO_Central.
DR GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR CDD; cd01047; ACSF; 1.
DR HAMAP; MF_01840; AcsF; 1.
DR InterPro; IPR008434; AcsF.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR003251; Rubrerythrin.
DR PANTHER; PTHR31053; PTHR31053; 1.
DR Pfam; PF02915; Rubrerythrin; 1.
DR SUPFAM; SSF47240; SSF47240; 1.
DR TIGRFAMs; TIGR02029; AcsF; 1.
PE 2: Evidence at transcript level;
KW Chlorophyll biosynthesis; Chloroplast; Iron; Metal-binding; NADP;
KW Oxidoreductase; Photosynthesis; Plastid; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..43
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 44..405
FT /note="Magnesium-protoporphyrin IX monomethyl ester
FT [oxidative] cyclase, chloroplastic"
FT /id="PRO_0000000602"
SQ SEQUENCE 405 AA; 47008 MW; 55BC9EEB09C0A807 CRC64;
MATEMALVKP ISKFSTSSPI FSNSRYGKFT TVRMSSTSQS TTKAAAKGGK KAAKTAIKET
LLTPRFYTTD FDEMEALFNT EINKNLNQSE FESLLQEFKT DYNQTHFVRN KEFKEAADKI
DGPLRQIFVE FSERSCTAEF SGFLLYKELG RRLKKTNPVV AEIFSLMSRD EARHAGFLNK
GLSDFNLALD LGFLTKARKY TFFKPKFIFY ATYLSEKIGY WRYITIYRHL KENPEYQCYP
IFKYFENWCQ DENRHGDFFS ALLKAQPQFL NDWKAKLWSR FFCLSVYVTM YLNDCQRTAF
YEGIGLDTKE FDMHVIIETN RTTARIFPAV LDVENPEFKR RLDKMVEINE QLLAVGETSD
IPLVKNLKRI PLIAALASEL LATYLMPPIE SGSVDFAEFE PQLVY
