ID   CRE12_PHYIT             Reviewed;         165 AA.
AC   D0NPE9;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=RxLR effector protein CRE12 {ECO:0000303|PubMed:29312401};
DE   AltName: Full=Core RXLR effector 12 {ECO:0000303|PubMed:29312401};
DE   Flags: Precursor;
GN   Name=CRE12 {ECO:0000303|PubMed:29312401}; ORFNames=PITG_14960;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   INDUCTION, DOMAIN, AND FUNCTION.
RX   PubMed=29312401; DOI=10.3389/fpls.2017.02155;
RA   Yin J., Gu B., Huang G., Tian Y., Quan J., Lindqvist-Kreuze H., Shan W.;
RT   "Conserved RXLR effector genes of Phytophthora infestans expressed at the
RT   early stage of potato infection are suppressive to host defense.";
RL   Front. Plant Sci. 8:2155-2155(2017).
CC   -!- FUNCTION: Effector that is involved in host plant infection.
CC       Contributes to virulence during the early infection stage, by
CC       inhibiting plant defense responses induced by both PAMP-triggered
CC       immunity (PTI) and effector-triggered immunity (ETI).
CC       {ECO:0000269|PubMed:29312401}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29312401}. Host cell
CC       {ECO:0000305|PubMed:29312401}.
CC   -!- INDUCTION: Expression is induced during host plant infection.
CC       {ECO:0000269|PubMed:29312401}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29312401}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; DS028150; EEY62491.1; -; Genomic_DNA.
DR   RefSeq; XP_002899127.1; XM_002899081.1.
DR   AlphaFoldDB; D0NPE9; -.
DR   SMR; D0NPE9; -.
DR   EnsemblProtists; PITG_14960T0; PITG_14960T0; PITG_14960.
DR   GeneID; 9468133; -.
DR   KEGG; pif:PITG_14960; -.
DR   VEuPathDB; FungiDB:PITG_14960; -.
DR   eggNOG; ENOG502RGSR; Eukaryota.
DR   HOGENOM; CLU_1655635_0_0_1; -.
DR   OMA; NTIANRF; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..165
FT                   /note="RxLR effector protein CRE12"
FT                   /id="PRO_5003013560"
FT   MOTIF           40..59
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29312401"
SQ   SEQUENCE   165 AA;  18268 MW;  C35DC93CA1C41425 CRC64;
     MRLAAFVLVA VAFAIIPDGR VSAAALGPPE SSEGTHEKAR LLRLNAVPQP VETGNQEERT
     INFASIKKIV PGTSAFKNAQ ALKASQKAAL KAQDAAKRKA AVDKWFKQFE SDEFLFTAAF
     PSWVRKKMHP DKVREYFASL GKSGDDVSMI VKRYDNYRQT IPTKK