ID   CRE2A_XENLA             Reviewed;         361 AA.
AC   Q5XH36;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 2-A;
DE   Flags: Precursor;
GN   Name=creld2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in neuronal acetylcholine receptor transport.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
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DR   EMBL; BC084239; AAH84239.1; -; mRNA.
DR   RefSeq; NP_001088243.1; NM_001094774.1.
DR   AlphaFoldDB; Q5XH36; -.
DR   DNASU; 495074; -.
DR   GeneID; 495074; -.
DR   KEGG; xla:495074; -.
DR   CTD; 495074; -.
DR   Xenbase; XB-GENE-999017; creld2.S.
DR   OrthoDB; 883628at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 495074; Expressed in liver and 18 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 2.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; LE_dom.
DR   Pfam; PF11938; DUF3456; 2.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Endoplasmic reticulum;
KW   Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..361
FT                   /note="Cysteine-rich with EGF-like domain protein 2-A"
FT                   /id="PRO_0000256249"
FT   DOMAIN          134..176
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          191..238
FT                   /note="FU 1"
FT   REPEAT          251..298
FT                   /note="FU 2"
FT   DOMAIN          288..329
FT                   /note="EGF-like 2; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REGION          341..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        303
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        352
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        138..152
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        146..164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        166..175
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        292..306
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        299..315
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        317..328
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   361 AA;  39745 MW;  D370C9AE4F00E08D CRC64;
     MNGSRALHLS AWLLLCLLCS AAVARDDSCE TCRKLVDRFH KGLENTAKKN FGGGNTAWEE
     KTLSKYESSE IRLVEIIENL CDSSDFECNH MVEEHEEQIE KWWFKMKKKY PDLLKWFCIE
     TIKVCCPPGT YGPDCLACLG GSERPCHGNG FCNGDGTRSG DGLCRCEAEY TGPFCLECAD
     EYFSSERNDT YSLCTACNQA CKTCDGPSNE DCKECKNGWI KDDGKCVDLN ECASEESPCK
     DSQYCLNTEG SFLCKECDGS CLGCSGEGPE NCKDCATGYV LLAEKCTDVD ECDASEQVCS
     RENETCLNTA GSYKCTCSEG FEDKEGNCVK IMEAENTEVT DGEMGTSASD INISNTAHED
     L