ID   CRE2B_XENLA             Reviewed;         361 AA.
AC   Q4V7M2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 2-B;
DE   Flags: Precursor;
GN   Name=creld2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in neuronal acetylcholine receptor transport.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC097826; AAH97826.1; -; mRNA.
DR   RefSeq; NP_001089538.1; NM_001096069.1.
DR   AlphaFoldDB; Q4V7M2; -.
DR   DNASU; 734593; -.
DR   GeneID; 734593; -.
DR   KEGG; xla:734593; -.
DR   CTD; 734593; -.
DR   Xenbase; XB-GENE-6255881; creld2.L.
DR   OMA; PEANECK; -.
DR   OrthoDB; 883628at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 734593; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 2.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; LE_dom.
DR   Pfam; PF11938; DUF3456; 2.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Endoplasmic reticulum;
KW   Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..361
FT                   /note="Cysteine-rich with EGF-like domain protein 2-B"
FT                   /id="PRO_0000256250"
FT   DOMAIN          134..176
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          191..238
FT                   /note="FU 1"
FT   REPEAT          251..298
FT                   /note="FU 2"
FT   DOMAIN          288..329
FT                   /note="EGF-like 2; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REGION          339..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        138..152
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        146..164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        166..175
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        292..306
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        299..315
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        317..328
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   361 AA;  39515 MW;  8E342A145975774A CRC64;
     MNGSRAWRLA AWLLLCLSCS AAVARKDSCE TCTKLVERFH KGLENTAKKN FGGGNTAWEE
     KTLSKYESSE IRLVEIIENI CDSSDFECNH MVEEHEEQIE KWWFKMKQKY PDLLKWFCIE
     AIKVCCPSGS YGPDCLACLG GSERPCHGNG FCSGDGTRSG DGSCRCKAEY TGSFCLECSD
     GYYSSERNDT HAVCIACNQA CKTCNGPSNE DCKECNNGWV KDDGKCVDLN ECASEESPCK
     DSQYCLNTEG SFLCKECDGS CSGCSGEGPE SCKDCATGFV MLSGKCTDVD ECDASEKLCL
     RENEVCLNTA GSYKCTCSEG FEDKEGNCVK IMETENPEIT EGETGTPASD TNILNTAHED
     L