CRE8_PHYIT
ID CRE8_PHYIT Reviewed; 168 AA.
AC D0NBU6;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 1.
DT 03-AUG-2022, entry version 31.
DE RecName: Full=RxLR effector protein CRE8 {ECO:0000303|PubMed:29312401};
DE AltName: Full=Core RXLR effector 8 {ECO:0000303|PubMed:29312401};
DE Flags: Precursor;
GN Name=CRE8 {ECO:0000303|PubMed:29312401}; ORFNames=PITG_09160;
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4;
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
RN [2]
RP INDUCTION, DOMAIN, AND FUNCTION.
RX PubMed=29312401; DOI=10.3389/fpls.2017.02155;
RA Yin J., Gu B., Huang G., Tian Y., Quan J., Lindqvist-Kreuze H., Shan W.;
RT "Conserved RXLR effector genes of Phytophthora infestans expressed at the
RT early stage of potato infection are suppressive to host defense.";
RL Front. Plant Sci. 8:2155-2155(2017).
CC -!- FUNCTION: Effector that is involved in host plant infection.
CC Contributes to virulence during the early infection stage, by
CC inhibiting plant defense responses induced by both PAMP-triggered
CC immunity (PTI) and effector-triggered immunity (ETI).
CC {ECO:0000269|PubMed:29312401}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29312401}. Host cell
CC {ECO:0000305|PubMed:29312401}.
CC -!- INDUCTION: Expression is induced during host plant infection.
CC {ECO:0000269|PubMed:29312401}.
CC -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC phosphate. {ECO:0000305|PubMed:29312401}.
CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR EMBL; DS028131; EEY55251.1; -; Genomic_DNA.
DR RefSeq; XP_002903475.1; XM_002903429.1.
DR AlphaFoldDB; D0NBU6; -.
DR SMR; D0NBU6; -.
DR EnsemblProtists; PITG_09160T0; PITG_09160T0; PITG_09160.
DR GeneID; 9470502; -.
DR KEGG; pif:PITG_09160; -.
DR VEuPathDB; FungiDB:PITG_09160; -.
DR HOGENOM; CLU_1605966_0_0_1; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal; Virulence.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..168
FT /note="RxLR effector protein CRE8"
FT /id="PRO_5003012487"
FT MOTIF 54..69
FT /note="RxLR-dEER"
FT /evidence="ECO:0000305|PubMed:29312401"
SQ SEQUENCE 168 AA; 18385 MW; 765BD0909424385A CRC64;
MRLPSILVVA ASTLFLHYGY TSASPGADAV LTGAVSLGFL QLVGADQSVI EQPRFLRDGK
IAEGDNEERV NAQKEAAAKV LDQVFKTKSL SPLDKLEKTS NLAVIRHVAA MVDDKVDKIF
AFADAVGMGR ASMLKMLKGD KQFTDAERLK TVKRYVKFLI KKEQNNKA
