ID   CRE9_PHYIT              Reviewed;         140 AA.
AC   D0NB65;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=RxLR effector protein CRE9 {ECO:0000303|PubMed:29312401};
DE   AltName: Full=Core RXLR effector 9 {ECO:0000303|PubMed:29312401};
DE   Flags: Precursor;
GN   Name=CRE9 {ECO:0000303|PubMed:29312401}; ORFNames=PITG_09224;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   INDUCTION, DOMAIN, AND FUNCTION.
RX   PubMed=29312401; DOI=10.3389/fpls.2017.02155;
RA   Yin J., Gu B., Huang G., Tian Y., Quan J., Lindqvist-Kreuze H., Shan W.;
RT   "Conserved RXLR effector genes of Phytophthora infestans expressed at the
RT   early stage of potato infection are suppressive to host defense.";
RL   Front. Plant Sci. 8:2155-2155(2017).
CC   -!- FUNCTION: Effector that is involved in host plant infection.
CC       Contributes to virulence during the early infection stage, by
CC       inhibiting plant defense responses induced by both PAMP-triggered
CC       immunity (PTI) and effector-triggered immunity (ETI).
CC       {ECO:0000269|PubMed:29312401}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29312401}. Host cell
CC       {ECO:0000305|PubMed:29312401}. Membrane {ECO:0000255}; Single-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is induced during host plant infection.
CC       {ECO:0000269|PubMed:29312401}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29312401}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; DS028131; EEY55294.1; -; Genomic_DNA.
DR   RefSeq; XP_002903518.1; XM_002903472.1.
DR   AlphaFoldDB; D0NB65; -.
DR   SMR; D0NB65; -.
DR   EnsemblProtists; PITG_09224T0; PITG_09224T0; PITG_09224.
DR   GeneID; 9470549; -.
DR   KEGG; pif:PITG_09224; -.
DR   VEuPathDB; FungiDB:PITG_09224; -.
DR   eggNOG; ENOG502SXR9; Eukaryota.
DR   HOGENOM; CLU_150342_0_0_1; -.
DR   InParanoid; D0NB65; -.
DR   OMA; WWATDEE; -.
DR   OrthoDB; 1593462at2759; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Secreted; Signal; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..140
FT                   /note="RxLR effector protein CRE9"
FT                   /id="PRO_5003012466"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           43..61
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29312401"
SQ   SEQUENCE   140 AA;  15221 MW;  4637012CCB3322A2 CRC64;
     MRTSVFVALV VATFVATCIS FTSAKNVAQI RDVDGGNNVQ ETRTLAEADD WWLASTNTEE
     RSGGAGFFSK LRGKVHAKQS SGVMTTQKLN DQQVKTITKE VATTVKKDRR TWPMIKKGLK
     ILYGALLAGL IIVGVEAMLS