ID   CREA_BOTFU              Reviewed;         435 AA.
AC   O94130;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=DNA-binding protein creA;
DE   AltName: Full=Carbon catabolite repressor;
GN   Name=creA;
OS   Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Botrytis.
OX   NCBI_TaxID=40559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SAS56;
RX   PubMed=10689158; DOI=10.1111/j.1574-6968.2000.tb08982.x;
RA   Tudzynski B., Liu S., Kelly J.M.;
RT   "Carbon catabolite repression in plant pathogenic fungi: isolation and
RT   characterization of the Gibberella fujikuroi and Botrytis cinerea creA
RT   genes.";
RL   FEMS Microbiol. Lett. 184:9-15(2000).
CC   -!- FUNCTION: Involved in carbon catabolite repression. Represses the
CC       transcription of a number of genes by binding to a GC-rich region in
CC       their promoter (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the creA/MIG C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; Y16625; CAA76329.1; -; Genomic_DNA.
DR   AlphaFoldDB; O94130; -.
DR   SMR; O94130; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..435
FT                   /note="DNA-binding protein creA"
FT                   /id="PRO_0000046873"
FT   ZN_FING         73..95
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         101..125
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          114..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..185
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  47525 MW;  BA9CE268A9CD474E CRC64;
     MQRASSAVDF NSLLNPPQSA QELEHQAARQ KLAIIQQQQQ HQREAEMAAM SMMAPTMVGG
     HHGDDRQDLP RPYKCPLCEK AFHRLEHQTR HIRTHTGEKP HACMFPGCTK RFSRSDELTR
     HSRIHNNPNS RRSNKAQQAP QMGVAMHSES MATMMPPPNK NITRSAPASA LGSPNVSPPH
     SYSSYSSNYL SSLNPHGRSL GGSPSNGQAP LTDINMLATA ATQVERESST TATHYSQHTQ
     PRHQPYYSHS SHNSRNHLPS LQAYAMTRAH SHEEDDHYAH RHAKRSRPNS PMSTAPSSPT
     FSHDSLSPTP DHTPLATPAH SPRLRPFGGG YDLPGIRNLS LHHTPALAPM EPQHLDGQYH
     TTATPTPPTT SAPRTGLTIS DIMSRTDGST RKLPVPQAPV AVQDLSSPGE IGFNTSGQSS
     TTGSVAGNDL ADRMI