ID   CREA_COCCA              Reviewed;         430 AA.
AC   Q9HFS2;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=DNA-binding protein creA;
DE   AltName: Full=Carbon catabolite repressor;
GN   Name=CREA;
OS   Cochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=5017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12825351; DOI=10.1080/1042517031000073727;
RA   Tonukari N.J., Scott-Craig J.S., Walton J.D.;
RT   "Isolation of the carbon catabolite repressor (CREA) gene from the plant-
RT   pathogenic fungus Cochliobolus carbonum.";
RL   DNA Seq. 14:103-107(2003).
CC   -!- FUNCTION: Involved in carbon catabolite repression. Represses the
CC       transcription of a number of genes by binding to a GC-rich region in
CC       their promoter (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the creA/MIG C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AF306571; AAG29826.1; -; mRNA.
DR   AlphaFoldDB; Q9HFS2; -.
DR   SMR; Q9HFS2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..430
FT                   /note="DNA-binding protein creA"
FT                   /id="PRO_0000046874"
FT   ZN_FING         68..90
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         96..120
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  46333 MW;  54F0F399F5B299DF CRC64;
     MQSNSASTGF ANLLNPETAS QNQQQQQQQP TSTPTASMAA ATVSLMAPLL QNAPQQTEEP
     RQDLPRPYKC PLCDKAFHRL EHQTRHIRTH TGEKPHACTF PGCTKRFSRS DELTRHSRIH
     NNPNSRRGKG QQHAAATQAA VAAVQAGLME PGSNLAHMMP PPSKPISRSA PGSQLGSPNV
     SPPHSFSNYS PGMSNDLAAY HQGGLSNSSS PSGLARPMDL LADAASRLEQ RPGHISHSSR
     HHLTSGYHPY ANRLPGLSQY AYSSQPMSRS HSHEDDDPYS HRMTKKSRPG SPSSTAPPSP
     TFSHDSCSPT PDHTPLATPA HSPRLRPHGF SDLQLPHLRH LSLNQNFVPA LAPMEPSTER
     EQPYVPSQSS GLRIGDIISK PEGAQRKLPV PQVPKVAVQD LLNGPSNSGF SSGNNSATAS
     LAGEDLSNRN