ID   CREA_ECOLI              Reviewed;         157 AA.
AC   P0AE91; P08367; Q2M5S0;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Protein CreA;
DE   AltName: Full=Catabolite regulation protein A;
DE   Flags: Precursor;
GN   Name=creA; Synonyms=yjjD; OrderedLocusNames=b4397, JW4360;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3531171; DOI=10.1128/jb.168.1.294-302.1986;
RA   Amemura M., Makino K., Shinagawa H., Nakata A.;
RT   "Nucleotide sequence of the phoM region of Escherichia coli: four open
RT   reading frames may constitute an operon.";
RL   J. Bacteriol. 168:294-302(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8449900; DOI=10.1016/s0021-9258(18)53330-5;
RA   Skarstad K., Thoeny B., Hwang D.S., Kornberg A.;
RT   "A novel binding protein of the origin of the Escherichia coli
RT   chromosome.";
RL   J. Biol. Chem. 268:5365-5370(1993).
RN   [6]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / DH5-alpha;
RX   PubMed=18375564; DOI=10.1128/jb.00108-08;
RA   Cariss S.J., Tayler A.E., Avison M.B.;
RT   "Defining the growth conditions and promoter-proximal DNA sequences
RT   required for activation of gene expression by CreBC in Escherichia coli.";
RL   J. Bacteriol. 190:3930-3939(2008).
CC   -!- DISRUPTION PHENOTYPE: No crucial effects on activation of cre regulon
CC       gene expression during aerobic growth on glucose or pyruvate minimal
CC       medium or during anaerobic growth on glucose minimal medium.
CC       {ECO:0000269|PubMed:18375564}.
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DR   EMBL; M13608; AAA24373.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97293.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77350.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78386.1; -; Genomic_DNA.
DR   EMBL; M97495; AAA24568.1; -; Genomic_DNA.
DR   PIR; A25038; QQECF1.
DR   RefSeq; NP_418814.1; NC_000913.3.
DR   RefSeq; WP_000875487.1; NZ_STEB01000033.1.
DR   AlphaFoldDB; P0AE91; -.
DR   BioGRID; 4259351; 10.
DR   IntAct; P0AE91; 1.
DR   STRING; 511145.b4397; -.
DR   jPOST; P0AE91; -.
DR   PaxDb; P0AE91; -.
DR   PRIDE; P0AE91; -.
DR   EnsemblBacteria; AAC77350; AAC77350; b4397.
DR   EnsemblBacteria; BAE78386; BAE78386; BAE78386.
DR   GeneID; 66671715; -.
DR   GeneID; 948920; -.
DR   KEGG; ecj:JW4360; -.
DR   KEGG; eco:b4397; -.
DR   PATRIC; fig|511145.12.peg.4546; -.
DR   EchoBASE; EB1200; -.
DR   eggNOG; COG3045; Bacteria.
DR   HOGENOM; CLU_109726_1_1_6; -.
DR   InParanoid; P0AE91; -.
DR   OMA; QGVTCYV; -.
DR   PhylomeDB; P0AE91; -.
DR   BioCyc; EcoCyc:EG11217-MON; -.
DR   PRO; PR:P0AE91; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR   InterPro; IPR010292; Uncharacterised_CreA.
DR   PANTHER; PTHR37952; PTHR37952; 1.
DR   Pfam; PF05981; CreA; 1.
DR   PIRSF; PIRSF003174; CreA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..157
FT                   /note="Protein CreA"
FT                   /id="PRO_0000079339"
SQ   SEQUENCE   157 AA;  17108 MW;  EC33001A09DC680F CRC64;
     MKYKHLILSL SLIMLGPLAH AEEIGSVDTV FKMIGPDHKI VVEAFDDPDV KNVTCYVSRA
     KTGGIKGGLG LAEDTSDAAI SCQQVGPIEL SDRIKNGKAQ GEVVFKKRTS LVFKSLQVVR
     FYDAKRNALA YLAYSDKVVE GSPKNAISAV PVMPWRQ