CREB5_HUMAN
ID CREB5_HUMAN Reviewed; 508 AA.
AC Q02930; A8KA51; B4DU13; B5BUH3; C9JK47; Q05886; Q06246; Q75N02; Q86UJ9;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 3.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Cyclic AMP-responsive element-binding protein 5;
DE Short=CREB-5;
DE Short=cAMP-responsive element-binding protein 5;
DE AltName: Full=cAMP-response element-binding protein A;
DE Short=CRE-BPa;
GN Name=CREB5; Synonyms=CREBPA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND SUBUNIT.
RX PubMed=8440710; DOI=10.1016/s0021-9258(18)53604-8;
RA Nomura N., Zu Y.-L., Maekawa T., Tabata S., Akiyama T., Ishii S.;
RT "Isolation and characterization of a novel member of the gene family
RT encoding the cAMP response element-binding protein CRE-BP1.";
RL J. Biol. Chem. 268:4259-4266(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), AND FUNCTION.
RX PubMed=8378084;
RA Zu Y.-L., Maekawa T., Nomura N., Nakata T., Ishii S.;
RT "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor
RT promoter TPA.";
RL Oncogene 8:2749-2758(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Embryo, Placenta, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=19054851; DOI=10.1038/nmeth.1273;
RA Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
RA Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
RA Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
RA Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y.,
RA Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A.,
RA Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y.,
RA Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T.,
RA Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y.,
RA Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S.,
RA Nomura N.;
RT "Human protein factory for converting the transcriptome into an in vitro-
RT expressed proteome.";
RL Nat. Methods 5:1011-1017(2008).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-59; THR-61 AND SER-137, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-50, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Binds to the cAMP response element and activates
CC transcription. {ECO:0000269|PubMed:8378084}.
CC -!- SUBUNIT: Binds DNA as a homodimer or as a heterodimer with JUN or
CC ATF2/CREBP1. {ECO:0000269|PubMed:8440710}.
CC -!- INTERACTION:
CC Q02930-3; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10192698, EBI-10173507;
CC Q02930-3; Q96IF1: AJUBA; NbExp=3; IntAct=EBI-10192698, EBI-949782;
CC Q02930-3; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-10192698, EBI-357530;
CC Q02930-3; P05187: ALPP; NbExp=3; IntAct=EBI-10192698, EBI-1211484;
CC Q02930-3; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-10192698, EBI-12224467;
CC Q02930-3; P54252: ATXN3; NbExp=3; IntAct=EBI-10192698, EBI-946046;
CC Q02930-3; Q9NR55: BATF3; NbExp=5; IntAct=EBI-10192698, EBI-10312707;
CC Q02930-3; Q6NVV7: CDPF1; NbExp=3; IntAct=EBI-10192698, EBI-2802782;
CC Q02930-3; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-10192698, EBI-12261896;
CC Q02930-3; A0PJX0: CIB4; NbExp=3; IntAct=EBI-10192698, EBI-12868028;
CC Q02930-3; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-10192698, EBI-12819063;
CC Q02930-3; P27658: COL8A1; NbExp=6; IntAct=EBI-10192698, EBI-747133;
CC Q02930-3; Q02930-3: CREB5; NbExp=3; IntAct=EBI-10192698, EBI-10192698;
CC Q02930-3; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-10192698, EBI-14156412;
CC Q02930-3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10192698, EBI-3867333;
CC Q02930-3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10192698, EBI-10976677;
CC Q02930-3; O95967: EFEMP2; NbExp=8; IntAct=EBI-10192698, EBI-743414;
CC Q02930-3; P23142-4: FBLN1; NbExp=3; IntAct=EBI-10192698, EBI-11956479;
CC Q02930-3; Q13643: FHL3; NbExp=3; IntAct=EBI-10192698, EBI-741101;
CC Q02930-3; P01100: FOS; NbExp=3; IntAct=EBI-10192698, EBI-852851;
CC Q02930-3; Q6FG41: FOS; NbExp=3; IntAct=EBI-10192698, EBI-10198738;
CC Q02930-3; P53539: FOSB; NbExp=3; IntAct=EBI-10192698, EBI-2806743;
CC Q02930-3; P15407: FOSL1; NbExp=6; IntAct=EBI-10192698, EBI-744510;
CC Q02930-3; P15408: FOSL2; NbExp=13; IntAct=EBI-10192698, EBI-3893419;
CC Q02930-3; O43559: FRS3; NbExp=3; IntAct=EBI-10192698, EBI-725515;
CC Q02930-3; P19883: FST; NbExp=5; IntAct=EBI-10192698, EBI-1571188;
CC Q02930-3; O15354: GPR37; NbExp=3; IntAct=EBI-10192698, EBI-15639515;
CC Q02930-3; P28799: GRN; NbExp=3; IntAct=EBI-10192698, EBI-747754;
CC Q02930-3; P28799-2: GRN; NbExp=3; IntAct=EBI-10192698, EBI-25860013;
CC Q02930-3; P49639: HOXA1; NbExp=5; IntAct=EBI-10192698, EBI-740785;
CC Q02930-3; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10192698, EBI-3918847;
CC Q02930-3; Q02535: ID3; NbExp=5; IntAct=EBI-10192698, EBI-1387094;
CC Q02930-3; P24592: IGFBP6; NbExp=3; IntAct=EBI-10192698, EBI-947015;
CC Q02930-3; Q5TA45: INTS11; NbExp=3; IntAct=EBI-10192698, EBI-748258;
CC Q02930-3; Q8WYK2: JDP2; NbExp=3; IntAct=EBI-10192698, EBI-1248415;
CC Q02930-3; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-10192698, EBI-2125614;
CC Q02930-3; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-10192698, EBI-14069005;
CC Q02930-3; Q5T749: KPRP; NbExp=5; IntAct=EBI-10192698, EBI-10981970;
CC Q02930-3; P19012: KRT15; NbExp=3; IntAct=EBI-10192698, EBI-739566;
CC Q02930-3; Q15323: KRT31; NbExp=3; IntAct=EBI-10192698, EBI-948001;
CC Q02930-3; Q6A162: KRT40; NbExp=6; IntAct=EBI-10192698, EBI-10171697;
CC Q02930-3; P78385: KRT83; NbExp=3; IntAct=EBI-10192698, EBI-10221390;
CC Q02930-3; P78386: KRT85; NbExp=3; IntAct=EBI-10192698, EBI-1049371;
CC Q02930-3; O43790: KRT86; NbExp=3; IntAct=EBI-10192698, EBI-9996498;
CC Q02930-3; Q8IUG1: KRTAP1-3; NbExp=5; IntAct=EBI-10192698, EBI-11749135;
CC Q02930-3; Q9BYS1: KRTAP1-5; NbExp=5; IntAct=EBI-10192698, EBI-11741292;
CC Q02930-3; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-10192698, EBI-11955579;
CC Q02930-3; P60412: KRTAP10-11; NbExp=6; IntAct=EBI-10192698, EBI-10217483;
CC Q02930-3; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-10192698, EBI-10172150;
CC Q02930-3; P60409: KRTAP10-7; NbExp=4; IntAct=EBI-10192698, EBI-10172290;
CC Q02930-3; P60410: KRTAP10-8; NbExp=10; IntAct=EBI-10192698, EBI-10171774;
CC Q02930-3; P60411: KRTAP10-9; NbExp=8; IntAct=EBI-10192698, EBI-10172052;
CC Q02930-3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10192698, EBI-11953334;
CC Q02930-3; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-10192698, EBI-12196745;
CC Q02930-3; Q7Z4W3: KRTAP19-3; NbExp=3; IntAct=EBI-10192698, EBI-12020132;
CC Q02930-3; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-10192698, EBI-1048945;
CC Q02930-3; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-10192698, EBI-12805508;
CC Q02930-3; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10192698, EBI-14065470;
CC Q02930-3; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10192698, EBI-9996449;
CC Q02930-3; Q9BYR7: KRTAP3-2; NbExp=8; IntAct=EBI-10192698, EBI-751260;
CC Q02930-3; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-10192698, EBI-11957260;
CC Q02930-3; Q9BQ66: KRTAP4-12; NbExp=9; IntAct=EBI-10192698, EBI-739863;
CC Q02930-3; Q9BYR5: KRTAP4-2; NbExp=9; IntAct=EBI-10192698, EBI-10172511;
CC Q02930-3; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10192698, EBI-11958132;
CC Q02930-3; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-10192698, EBI-11993254;
CC Q02930-3; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10192698, EBI-11993296;
CC Q02930-3; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10192698, EBI-11958178;
CC Q02930-3; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-10192698, EBI-11963072;
CC Q02930-3; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-10192698, EBI-10250562;
CC Q02930-3; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10192698, EBI-11987425;
CC Q02930-3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-10192698, EBI-3958099;
CC Q02930-3; Q3LI64: KRTAP6-1; NbExp=5; IntAct=EBI-10192698, EBI-12111050;
CC Q02930-3; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-10192698, EBI-11962084;
CC Q02930-3; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-10192698, EBI-18394498;
CC Q02930-3; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-10192698, EBI-10261141;
CC Q02930-3; Q9BYQ4: KRTAP9-2; NbExp=13; IntAct=EBI-10192698, EBI-1044640;
CC Q02930-3; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10192698, EBI-1043191;
CC Q02930-3; Q9BYQ2: KRTAP9-4; NbExp=5; IntAct=EBI-10192698, EBI-10185730;
CC Q02930-3; Q9BYQ0: KRTAP9-8; NbExp=5; IntAct=EBI-10192698, EBI-11958364;
CC Q02930-3; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10192698, EBI-12224199;
CC Q02930-3; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-10192698, EBI-10246607;
CC Q02930-3; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10192698, EBI-11973993;
CC Q02930-3; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-10192698, EBI-10246358;
CC Q02930-3; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-10192698, EBI-11955689;
CC Q02930-3; Q9UHV8: LGALS13; NbExp=3; IntAct=EBI-10192698, EBI-3957707;
CC Q02930-3; Q99732: LITAF; NbExp=3; IntAct=EBI-10192698, EBI-725647;
CC Q02930-3; O60663-2: LMX1B; NbExp=3; IntAct=EBI-10192698, EBI-10258690;
CC Q02930-3; Q99750: MDFI; NbExp=8; IntAct=EBI-10192698, EBI-724076;
CC Q02930-3; P55198: MLLT6; NbExp=3; IntAct=EBI-10192698, EBI-740216;
CC Q02930-3; Q9H3L0: MMADHC; NbExp=5; IntAct=EBI-10192698, EBI-11111575;
CC Q02930-3; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10192698, EBI-742948;
CC Q02930-3; Q6IA69: NADSYN1; NbExp=3; IntAct=EBI-10192698, EBI-748610;
CC Q02930-3; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10192698, EBI-945833;
CC Q02930-3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10192698, EBI-22310682;
CC Q02930-3; Q92824-2: PCSK5; NbExp=6; IntAct=EBI-10192698, EBI-11956269;
CC Q02930-3; O15496: PLA2G10; NbExp=3; IntAct=EBI-10192698, EBI-726466;
CC Q02930-3; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-10192698, EBI-3957793;
CC Q02930-3; Q9BYM8: RBCK1; NbExp=3; IntAct=EBI-10192698, EBI-2340624;
CC Q02930-3; P10745: RBP3; NbExp=3; IntAct=EBI-10192698, EBI-12806054;
CC Q02930-3; Q93062: RBPMS; NbExp=3; IntAct=EBI-10192698, EBI-740322;
CC Q02930-3; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-10192698, EBI-740343;
CC Q02930-3; Q96PM5: RCHY1; NbExp=3; IntAct=EBI-10192698, EBI-947779;
CC Q02930-3; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10192698, EBI-3918154;
CC Q02930-3; O76081: RGS20; NbExp=3; IntAct=EBI-10192698, EBI-1052678;
CC Q02930-3; O76081-6: RGS20; NbExp=6; IntAct=EBI-10192698, EBI-10178530;
CC Q02930-3; Q9UFD9: RIMBP3; NbExp=3; IntAct=EBI-10192698, EBI-10182375;
CC Q02930-3; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-10192698, EBI-751555;
CC Q02930-3; O15304-2: SIVA1; NbExp=3; IntAct=EBI-10192698, EBI-12372219;
CC Q02930-3; O75971-2: SNAPC5; NbExp=3; IntAct=EBI-10192698, EBI-12004298;
CC Q02930-3; Q7Z6I5: SPATA12; NbExp=3; IntAct=EBI-10192698, EBI-10696971;
CC Q02930-3; Q6IQ16: SPOPL; NbExp=3; IntAct=EBI-10192698, EBI-2822161;
CC Q02930-3; Q7Z699: SPRED1; NbExp=6; IntAct=EBI-10192698, EBI-5235340;
CC Q02930-3; O43609: SPRY1; NbExp=8; IntAct=EBI-10192698, EBI-3866665;
CC Q02930-3; O43597: SPRY2; NbExp=3; IntAct=EBI-10192698, EBI-742487;
CC Q02930-3; O43610: SPRY3; NbExp=3; IntAct=EBI-10192698, EBI-12290641;
CC Q02930-3; Q9C004: SPRY4; NbExp=3; IntAct=EBI-10192698, EBI-354861;
CC Q02930-3; Q12888: TP53BP1; NbExp=3; IntAct=EBI-10192698, EBI-396540;
CC Q02930-3; Q12933: TRAF2; NbExp=6; IntAct=EBI-10192698, EBI-355744;
CC Q02930-3; P36406: TRIM23; NbExp=3; IntAct=EBI-10192698, EBI-740098;
CC Q02930-3; P14373: TRIM27; NbExp=3; IntAct=EBI-10192698, EBI-719493;
CC Q02930-3; Q8IWZ5: TRIM42; NbExp=6; IntAct=EBI-10192698, EBI-5235829;
CC Q02930-3; Q15654: TRIP6; NbExp=3; IntAct=EBI-10192698, EBI-742327;
CC Q02930-3; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-10192698, EBI-744794;
CC Q02930-3; O14817: TSPAN4; NbExp=3; IntAct=EBI-10192698, EBI-8652667;
CC Q02930-3; Q969E8: TSR2; NbExp=3; IntAct=EBI-10192698, EBI-746981;
CC Q02930-3; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-10192698, EBI-12068150;
CC Q02930-3; Q9H9P5-5: UNKL; NbExp=3; IntAct=EBI-10192698, EBI-12817837;
CC Q02930-3; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-10192698, EBI-12040603;
CC Q02930-3; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-10192698, EBI-7850213;
CC Q02930-3; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-10192698, EBI-373456;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=Alpha;
CC IsoId=Q02930-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta;
CC IsoId=Q02930-2; Sequence=VSP_050010;
CC Name=3; Synonyms=Gamma;
CC IsoId=Q02930-3; Sequence=VSP_050011;
CC Name=4; Synonyms=Delta;
CC IsoId=Q02930-4; Sequence=VSP_050012, VSP_050013;
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; L05515; AAA52072.1; -; mRNA.
DR EMBL; L05911; AAC37525.1; -; mRNA.
DR EMBL; L05912; AAC37527.1; -; mRNA.
DR EMBL; L05913; AAC37526.1; -; mRNA.
DR EMBL; AK292916; BAF85605.1; -; mRNA.
DR EMBL; AK300455; BAG62175.1; -; mRNA.
DR EMBL; AK316187; BAH14558.1; -; mRNA.
DR EMBL; AB451409; BAG70223.1; -; mRNA.
DR EMBL; AC003074; AAS00387.1; -; Genomic_DNA.
DR EMBL; AC005105; AAP22329.1; -; Genomic_DNA.
DR EMBL; AC005013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471073; EAW93908.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW93910.1; -; Genomic_DNA.
DR EMBL; BC059400; AAH59400.2; -; mRNA.
DR CCDS; CCDS43562.1; -. [Q02930-3]
DR CCDS; CCDS43563.1; -. [Q02930-4]
DR CCDS; CCDS5417.1; -. [Q02930-1]
DR CCDS; CCDS5418.1; -. [Q02930-2]
DR PIR; A45477; A45477.
DR PIR; I78877; I78877.
DR RefSeq; NP_001011666.1; NM_001011666.2. [Q02930-4]
DR RefSeq; NP_004895.2; NM_004904.3. [Q02930-2]
DR RefSeq; NP_878901.2; NM_182898.3. [Q02930-1]
DR RefSeq; NP_878902.2; NM_182899.4. [Q02930-3]
DR RefSeq; XP_005249963.1; XM_005249906.1. [Q02930-2]
DR RefSeq; XP_016868295.1; XM_017012806.1. [Q02930-2]
DR RefSeq; XP_016868297.1; XM_017012808.1. [Q02930-1]
DR AlphaFoldDB; Q02930; -.
DR SMR; Q02930; -.
DR BioGRID; 114954; 155.
DR IntAct; Q02930; 135.
DR MINT; Q02930; -.
DR STRING; 9606.ENSP00000350359; -.
DR iPTMnet; Q02930; -.
DR PhosphoSitePlus; Q02930; -.
DR BioMuta; CREB5; -.
DR DMDM; 334302918; -.
DR jPOST; Q02930; -.
DR MassIVE; Q02930; -.
DR MaxQB; Q02930; -.
DR PaxDb; Q02930; -.
DR PeptideAtlas; Q02930; -.
DR PRIDE; Q02930; -.
DR ProteomicsDB; 58137; -. [Q02930-1]
DR ProteomicsDB; 58138; -. [Q02930-2]
DR ProteomicsDB; 58139; -. [Q02930-3]
DR ProteomicsDB; 58140; -. [Q02930-4]
DR Antibodypedia; 12490; 218 antibodies from 25 providers.
DR DNASU; 9586; -.
DR Ensembl; ENST00000357727.7; ENSP00000350359.2; ENSG00000146592.17. [Q02930-1]
DR Ensembl; ENST00000396298.6; ENSP00000379592.2; ENSG00000146592.17. [Q02930-4]
DR Ensembl; ENST00000396299.6; ENSP00000379593.2; ENSG00000146592.17. [Q02930-3]
DR Ensembl; ENST00000396300.6; ENSP00000379594.2; ENSG00000146592.17. [Q02930-2]
DR Ensembl; ENST00000409603.5; ENSP00000387197.1; ENSG00000146592.17. [Q02930-3]
DR GeneID; 9586; -.
DR KEGG; hsa:9586; -.
DR MANE-Select; ENST00000357727.7; ENSP00000350359.2; NM_182898.4; NP_878901.2.
DR UCSC; uc003szo.4; human. [Q02930-1]
DR CTD; 9586; -.
DR DisGeNET; 9586; -.
DR GeneCards; CREB5; -.
DR HGNC; HGNC:16844; CREB5.
DR HPA; ENSG00000146592; Tissue enhanced (brain).
DR MIM; 618262; gene.
DR neXtProt; NX_Q02930; -.
DR OpenTargets; ENSG00000146592; -.
DR PharmGKB; PA134930491; -.
DR VEuPathDB; HostDB:ENSG00000146592; -.
DR eggNOG; KOG1414; Eukaryota.
DR GeneTree; ENSGT00940000156420; -.
DR HOGENOM; CLU_021564_0_0_1; -.
DR InParanoid; Q02930; -.
DR OMA; MEMMPSR; -.
DR OrthoDB; 978850at2759; -.
DR PhylomeDB; Q02930; -.
DR PathwayCommons; Q02930; -.
DR SignaLink; Q02930; -.
DR SIGNOR; Q02930; -.
DR BioGRID-ORCS; 9586; 21 hits in 1108 CRISPR screens.
DR ChiTaRS; CREB5; human.
DR GeneWiki; CREB5; -.
DR GenomeRNAi; 9586; -.
DR Pharos; Q02930; Tbio.
DR PRO; PR:Q02930; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q02930; protein.
DR Bgee; ENSG00000146592; Expressed in synovial joint and 177 other tissues.
DR ExpressionAtlas; Q02930; baseline and differential.
DR Genevisible; Q02930; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0035497; F:cAMP response element binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR016378; TF_CRE-BP1-typ.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00170; bZIP_1; 1.
DR PIRSF; PIRSF003153; ATF2_CRE-BP1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Isopeptide bond;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..508
FT /note="Cyclic AMP-responsive element-binding protein 5"
FT /id="PRO_0000076604"
FT DOMAIN 375..438
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT ZN_FING 16..40
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 265..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..397
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 403..431
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 449..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..326
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 59
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 61
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CROSSLNK 50
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..33
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:8378084"
FT /id="VSP_050011"
FT VAR_SEQ 1..16
FT /note="MIYEESKMNLEQERPF -> MFCTSGGNSASVMSMR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8378084"
FT /id="VSP_050012"
FT VAR_SEQ 1..7
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8378084"
FT /id="VSP_050010"
FT VAR_SEQ 17..155
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8378084"
FT /id="VSP_050013"
FT CONFLICT 16
FT /note="F -> S (in Ref. 1; AAA52072 and 2; AAC37525)"
FT /evidence="ECO:0000305"
FT CONFLICT 211..212
FT /note="MQ -> IE (in Ref. 1; AAA52072 and 2; AAC37525/
FT AAC37526/AAC37527)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 508 AA; 56918 MW; DF96F33AE562F1AD CRC64;
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK TDNMLSDQTP
TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS MHNAVGGAMT GPGTHQLSSA
RLPNHDTNVV IQQAMPSPQS SSVITQAPST NRQIGPVPGS LSSLLHLHNR QRQPMPASMP
GTLPNPTMPG SSAVLMPMER QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL
THHPAAMSNG NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH
PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM QPTQTIQPPQ
PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV MSLEKKAEEL TQTNMQLQNE
VSMLKNEVAQ LKQLLLTHKD CPITAMQKES QGYLSPESSP PASPVPACSQ QQVIQHNTIT
TSSSVSEVVG SSTLSQLTTH RTDLNPIL
