CREB5_MOUSE
ID CREB5_MOUSE Reviewed; 357 AA.
AC Q8K1L0; Q3TCE1; Q3U228; Q8BWH8;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 3.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Cyclic AMP-responsive element-binding protein 5;
DE Short=CREB-5;
DE Short=cAMP-responsive element-binding protein 5;
DE AltName: Full=CRE-BPa;
GN Name=Creb5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAH29022.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-357 (ISOFORM 1).
RC TISSUE=Mammary gland {ECO:0000269|PubMed:15489334};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds to the cAMP response element and activates
CC transcription. {ECO:0000250|UniProtKB:Q02930}.
CC -!- SUBUNIT: Binds DNA as a homodimer or as a heterodimer with JUN or
CC ATF2/CREBP1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K1L0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K1L0-2; Sequence=VSP_022061, VSP_022062, VSP_022063;
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000255|RuleBase:RU000470,
CC ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH29022.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK052451; BAC34998.1; -; mRNA.
DR EMBL; AK154148; BAE32408.1; -; mRNA.
DR EMBL; AK155537; BAE33314.1; -; mRNA.
DR EMBL; AK170766; BAE42016.1; -; mRNA.
DR EMBL; BC029022; AAH29022.1; ALT_INIT; mRNA.
DR CCDS; CCDS20153.1; -. [Q8K1L0-1]
DR RefSeq; NP_001314750.1; NM_001327821.1.
DR RefSeq; NP_766316.1; NM_172728.2.
DR AlphaFoldDB; Q8K1L0; -.
DR SMR; Q8K1L0; -.
DR BioGRID; 231205; 2.
DR STRING; 10090.ENSMUSP00000038532; -.
DR PhosphoSitePlus; Q8K1L0; -.
DR MaxQB; Q8K1L0; -.
DR PaxDb; Q8K1L0; -.
DR PeptideAtlas; Q8K1L0; -.
DR PRIDE; Q8K1L0; -.
DR ProteomicsDB; 277892; -. [Q8K1L0-1]
DR ProteomicsDB; 277893; -. [Q8K1L0-2]
DR DNASU; 231991; -.
DR GeneID; 231991; -.
DR KEGG; mmu:231991; -.
DR UCSC; uc009bzf.2; mouse. [Q8K1L0-2]
DR UCSC; uc009bzi.1; mouse. [Q8K1L0-1]
DR CTD; 9586; -.
DR MGI; MGI:2443973; Creb5.
DR eggNOG; KOG1414; Eukaryota.
DR InParanoid; Q8K1L0; -.
DR OrthoDB; 978850at2759; -.
DR PhylomeDB; Q8K1L0; -.
DR BioGRID-ORCS; 231991; 6 hits in 39 CRISPR screens.
DR ChiTaRS; Creb5; mouse.
DR PRO; PR:Q8K1L0; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8K1L0; protein.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0035497; F:cAMP response element binding; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0060612; P:adipose tissue development; IGI:MGI.
DR GO; GO:0045444; P:fat cell differentiation; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050872; P:white fat cell differentiation; IMP:MGI.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR016378; TF_CRE-BP1-typ.
DR Pfam; PF00170; bZIP_1; 1.
DR PIRSF; PIRSF003153; ATF2_CRE-BP1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..357
FT /note="Cyclic AMP-responsive element-binding protein 5"
FT /id="PRO_0000076605"
FT DOMAIN 224..287
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 114..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..246
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 252..280
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 298..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..175
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..4
FT /note="MSMR -> MNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKT
FT DNMLSDQTPTPTRFLKNCEEVGLFSELDCSFEHEFRKAQEEENSKRNISMHNTVGGTMT
FT GPGAHQLGSTRMPNHDSSVVIQQAMPSPQSSSVITQAPSTNRQIG (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022061"
FT VAR_SEQ 84..97
FT /note="RLKAALTHHPAAMS -> NLHRPSPLALCLHS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022062"
FT VAR_SEQ 98..357
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022063"
FT CONFLICT 185
FT /note="H -> P (in Ref. 2; BAC34998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 39955 MW; 526F9818C81D7FB7 CRC64;
MSMRPVPGSL SSLLHLHNRQ RQPMPASMPG TLPNPTMPGS SAVLMPMERQ MSVNSSIMGM
QGPNLSNPCA SPQVQPMHSE AKMRLKAALT HHPAAMSNGN MSTIGHMMEM MGSRQDQTPH
HHLHSHPHQH QTLPPHHPYP HQHQHPAHHP HPQPHHQQNH PHHHSHSHLH AHPAHHQTSP
HPPLHTGNQA QVSPATQQMQ PTQTIQPPQP TGGRRRRVVD EDPDERRRKF LERNRAAATR
CRQKRKVWVM SLEKKAEELT QTNMQLQNEV SMLKNEVAQL KQLLLTHKDC PITAMQKESQ
GYLSPESSPP ASPVPACSQQ QVIQHNTITT SSSVSEVVGS STLSQLTTHR TDLNPIL
