CREB_ECOLI
ID CREB_ECOLI Reviewed; 229 AA.
AC P08368; Q2M5R9;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Transcriptional regulatory protein CreB;
GN Name=creB; Synonyms=yjjE; OrderedLocusNames=b4398, JW4361;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3531171; DOI=10.1128/jb.168.1.294-302.1986;
RA Amemura M., Makino K., Shinagawa H., Nakata A.;
RT "Nucleotide sequence of the phoM region of Escherichia coli: four open
RT reading frames may constitute an operon.";
RL J. Bacteriol. 168:294-302(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP PHOSPHORYLATION.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=15522865; DOI=10.1074/jbc.m410104200;
RA Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.;
RT "Functional characterization in vitro of all two-component signal
RT transduction systems from Escherichia coli.";
RL J. Biol. Chem. 280:1448-1456(2005).
CC -!- FUNCTION: Member of the two-component regulatory system CreC/CreB
CC involved in catabolic regulation.
CC -!- INTERACTION:
CC P08368; P08368: creB; NbExp=2; IntAct=EBI-1131567, EBI-1131567;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by CreC. {ECO:0000269|PubMed:15522865}.
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DR EMBL; M13608; AAA24374.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97294.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77351.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78387.1; -; Genomic_DNA.
DR PIR; B25038; QQECFJ.
DR RefSeq; NP_418815.1; NC_000913.3.
DR RefSeq; WP_001188654.1; NZ_LN832404.1.
DR AlphaFoldDB; P08368; -.
DR SMR; P08368; -.
DR BioGRID; 4263252; 1.
DR BioGRID; 853198; 4.
DR DIP; DIP-9318N; -.
DR IntAct; P08368; 4.
DR STRING; 511145.b4398; -.
DR PaxDb; P08368; -.
DR PRIDE; P08368; -.
DR EnsemblBacteria; AAC77351; AAC77351; b4398.
DR EnsemblBacteria; BAE78387; BAE78387; BAE78387.
DR GeneID; 948922; -.
DR KEGG; ecj:JW4361; -.
DR KEGG; eco:b4398; -.
DR PATRIC; fig|1411691.4.peg.2286; -.
DR EchoBASE; EB1201; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_4_6; -.
DR InParanoid; P08368; -.
DR OMA; KRLGEPW; -.
DR PhylomeDB; P08368; -.
DR BioCyc; EcoCyc:CREB-MON; -.
DR PRO; PR:P08368; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:EcoCyc.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..229
FT /note="Transcriptional regulatory protein CreB"
FT /id="PRO_0000081082"
FT DOMAIN 5..119
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 129..228
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 54
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 229 AA; 26125 MW; A982C6D832C7607B CRC64;
MQRETVWLVE DEQGIADTLV YMLQQEGFAV EVFERGLPVL DKARKQVPDV MILDVGLPDI
SGFELCRQLL ALHPALPVLF LTARSEEVDR LLGLEIGADD YVAKPFSPRE VCARVRTLLR
RVKKFSTPSP VIRIGHFELN EPAAQISWFD TPLALTRYEF LLLKTLLKSP GRVWSRQQLM
DSVWEDAQDT YDRTVDTHIK TLRAKLRAIN PDLSPINTHR GMGYSLRGL
