ID   CREB_HYDVD              Reviewed;         249 AA.
AC   P51984;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Cyclic AMP-responsive element-binding protein;
DE            Short=cAMP-responsive element-binding protein;
DE   AltName: Full=cAMP response element-binding protein;
GN   Name=CREB;
OS   Hydra viridissima (Green hydra) (Chlorohydra viridissima).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6082;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7743932; DOI=10.1242/dev.121.4.1205;
RA   Galliot B., Welschof M., Schuckert O., Hoffmeister S., Schaller H.C.;
RT   "The cAMP response element binding protein is involved in hydra
RT   regeneration.";
RL   Development 121:1205-1216(1995).
CC   -!- FUNCTION: This protein binds the cAMP response element (CRE), sequence
CC       present in many viral and cellular promoters. Could regulate the
CC       transcriptional activity of genes involved in regeneration processes.
CC   -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR   EMBL; X83873; CAA58753.1; -; Genomic_DNA.
DR   AlphaFoldDB; P51984; -.
DR   SMR; P51984; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR003102; Coactivator_CBP_pKID.
DR   InterPro; IPR001630; Leuzip_CREB.
DR   PANTHER; PTHR45879; PTHR45879; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   Pfam; PF02173; pKID; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
DR   PROSITE; PS50953; KID; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..249
FT                   /note="Cyclic AMP-responsive element-binding protein"
FT                   /id="PRO_0000076610"
FT   DOMAIN          35..94
FT                   /note="KID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00312"
FT   DOMAIN          191..249
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          73..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..217
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          219..240
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   COMPBIAS        88..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   249 AA;  27950 MW;  5E998A5D2F75A30B CRC64;
     MELARHSFQQ PLNVAPSLSN VVNKTSVVLQ QQSVIQPNQH QLQHQLQTMH DGGIDGKRRE
     ILARRPSYRR ILDDLAGDGP VKMENYDDTG SSGESSPNGN NEEDINGINQ SVSHQEKQYQ
     SIHLNGIVSS VQGGENSLNQ LHDSQPGDNQ YIITTQGPDN KIQAYTIKGT LPIGLDNTSL
     ASPHQLAEEA TRKRELRLYK NREAARECRR KKKEYVKCLE NRVAVLENQN KALIEELKSL
     KDLYCSKGD