ID   CREB_HYDVU              Reviewed;         217 AA.
AC   P51985;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Cyclic AMP-responsive element-binding protein;
DE            Short=cAMP-responsive element-binding protein;
DE   AltName: Full=cAMP response element-binding protein;
GN   Name=CREB;
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
RX   PubMed=7743932; DOI=10.1242/dev.121.4.1205;
RA   Galliot B., Welschof M., Schuckert O., Hoffmeister S., Schaller H.C.;
RT   "The cAMP response element binding protein is involved in hydra
RT   regeneration.";
RL   Development 121:1205-1216(1995).
CC   -!- FUNCTION: This protein binds the cAMP response element (CRE), a
CC       sequence present in many viral and cellular promoters. Could regulate
CC       the transcriptional activity of genes involved in regeneration
CC       processes.
CC   -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=Alpha;
CC         IsoId=P51985-1; Sequence=Displayed;
CC       Name=Beta;
CC         IsoId=P51985-2; Sequence=VSP_000608;
CC   -!- DOMAIN: In contrast to other proteins of the family, the C-terminus is
CC       shorter and lacks the leucine-zipper.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR   EMBL; X83872; CAA58752.1; -; mRNA.
DR   RefSeq; NP_001296614.1; NM_001309685.1. [P51985-1]
DR   AlphaFoldDB; P51985; -.
DR   SMR; P51985; -.
DR   GeneID; 100200223; -.
DR   KEGG; hmg:100200223; -.
DR   OrthoDB; 957343at2759; -.
DR   Proteomes; UP000694840; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR003102; Coactivator_CBP_pKID.
DR   InterPro; IPR001630; Leuzip_CREB.
DR   PANTHER; PTHR45879; PTHR45879; 1.
DR   Pfam; PF02173; pKID; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
DR   PROSITE; PS50953; KID; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..217
FT                   /note="Cyclic AMP-responsive element-binding protein"
FT                   /id="PRO_0000076611"
FT   DOMAIN          34..93
FT                   /note="KID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00312"
FT   REGION          73..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..211
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        87..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         145..162
FT                   /note="Missing (in isoform Beta)"
FT                   /evidence="ECO:0000303|PubMed:7743932"
FT                   /id="VSP_000608"
SQ   SEQUENCE   217 AA;  24361 MW;  9AFAECA2179AF598 CRC64;
     MELARHSFQQ PLNVAPSLSN VNKTSVVLQQ QSVIQSNQHQ LQHQLQNMHD GGIEGKRREI
     LARRPSYRRI LDDLAGDGPV KMENYDDTGS SGESSPNGNN EEDINGINPN SIHQEKQYQN
     IHLNGIVSSV QGGENSMNQL HDSQPGDNQY IITAQGPDNK IQAYTIKGTL PMGLDNTSLA
     SPHQLAEEAT RKRELRLYKN REAARECRRK KTHTETF