ID   CREC_ASPCL              Reviewed;         573 AA.
AC   A1CTE6;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Probable catabolite repression protein creC;
GN   Name=creC; ORFNames=ACLA_082740;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW06583.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS027060; EAW06583.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001268009.1; XM_001268008.1.
DR   AlphaFoldDB; A1CTE6; -.
DR   SMR; A1CTE6; -.
DR   STRING; 5057.CADACLAP00007687; -.
DR   EnsemblFungi; EAW06583; EAW06583; ACLA_082740.
DR   GeneID; 4700512; -.
DR   KEGG; act:ACLA_082740; -.
DR   eggNOG; KOG2394; Eukaryota.
DR   OrthoDB; 907634at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..573
FT                   /note="Probable catabolite repression protein creC"
FT                   /id="PRO_0000395686"
FT   REPEAT          225..265
FT                   /note="WD 1"
FT   REPEAT          305..346
FT                   /note="WD 2"
FT   REPEAT          347..386
FT                   /note="WD 3"
FT   REPEAT          389..433
FT                   /note="WD 4"
FT   REPEAT          505..542
FT                   /note="WD 5"
FT   REGION          448..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   573 AA;  63217 MW;  CB54FBB844331A15 CRC64;
     MAVPVIETNN IISHPEGGCP LQVGEGTYHL KDNLHLATPP PHPSEAPIVN PNPLATVPTP
     PTMGVKLSLI CISPRTKTPS SLPNQTVVAP PFGDGNPALA PVPVKDGLKR RKPKNNIIKS
     SSSFVSRVIT HEAATKRLND RSPEGLFAFA NINRAFQWLD LSSKQKEEPL TKILFTKAHM
     LCHDTNELTK SSSHIDIVMG SSAGDIIWYE PMSQKYARIN KNGVVSNSPV THIKWIPGSE
     NLFMAAHANG QLAVYDKEKE DALFTPEIQN QSAEALKASG RQPLQVLKSV NSRNQKTNPV
     ALWKLANQRI SHFAFSPDQR HLAVVLEDGS LRVMDYLKEE VLDIFRSYYG GLICVCWSPD
     GKYIVTGGQD DLLTIWSLPE RKIVARCQGH NSWVSAVAFD PWRCDERTYR FGSVGDDCRL
     LLWDFSVGML HRPKVYQASA RQRTSMITSN TQYGNRHRAD SASNRMRSDS QKTANTYESC
     DQAVRHPVEP RARTALLPPI MSKVVGSDPI CWLGFQEDCI MTSSLEGHIR TWDRPREGIS
     DKYNDQSSSP AISASATGSG SVSGLADSNT GLS