ID   CREC_ASPFC              Reviewed;         566 AA.
AC   B0Y7H6;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Probable catabolite repression protein creC;
GN   Name=creC; ORFNames=AFUB_073840;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the regulatory network controlling carbon source
CC       utilization through ubiquitination and deubiquitination involving creA,
CC       creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC       CreB deubiquitinating enzyme in the absence of carbon catabolite
CC       repression. CreB deubiquitinating enzyme stabilized in a complex with
CC       the CreC leads to the expression of genes such as those in the proline
CC       and quinate pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with creB. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat creC family. {ECO:0000305}.
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DR   EMBL; DS499599; EDP49357.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0Y7H6; -.
DR   SMR; B0Y7H6; -.
DR   PhylomeDB; B0Y7H6; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN           1..566
FT                   /note="Probable catabolite repression protein creC"
FT                   /id="PRO_0000395687"
FT   REPEAT          225..265
FT                   /note="WD 1"
FT   REPEAT          305..340
FT                   /note="WD 2"
FT   REPEAT          341..379
FT                   /note="WD 3"
FT   REPEAT          382..426
FT                   /note="WD 4"
FT   REPEAT          498..535
FT                   /note="WD 5"
FT   REGION          433..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..566
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   566 AA;  62293 MW;  271EE5CF15D84780 CRC64;
     MAVPVVETNN ILSHPEGGCP LQVGEGTYEL KDDLHLATPP PHPSEAPIIN PNPLATVPTP
     PTSGVKVSLV CVSPRSRTPS FISKQIVTAP PFGDGNPALV PAPVKDGLKR RKPKNNIIKS
     SSSFVSRVIT HEVATKRLSE RSPEGLFAFA NINRAFQWLD LSSKQKEDPL AKILFTKAHM
     LCHDINEVTK SPSHIDVVMG SSAGDIIWYE PISQKYARIN KNGVVCNSPV THIKWIPGSE
     NLFMASHANG QLVVYDKEKE DALFTPEIQD QSAEAVKASS TQPLQVLKSV NSRNQKTNPV
     ALWKLANQRI SHFAFSPDQR HLAVVLEDGS LRVMDYLKED YYGGLICVCW SPDGKYIVTG
     GQDDLVTIWS FPERKIVARC QGHNSWVSAV AFDPWQCDER TYRFGSVGDD CRLLLWDFSV
     GMLHRPKVHQ TSARQRTSMV AGSSQYGNRH RADSVGNRMR SDSQRTANTY ESCDQAVRHP
     VEPRARTALL PPIMSKVVGT DPICWLGFQE DCIMTSSLEG HIRTWDRPRE GINDKYNDQS
     SSTAVSASAA GSGSISGLAE STMGSL